Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase

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Rosa L.E. Loon; Beatrijs eBartelds; Beatrijs eBartelds; Frank A.D.T.G. Wagener; Nada eAffara; Saffloer eMohaupt; Hans eWijnberg; Sebastiaan W.C. Pennings; Janny eTakens; Rolf M.F. Berger; Rolf M.F. Berger; (2015)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Pediatrics (issn: 2296-2360)
  • Related identifiers: doi: 10.3389/fped.2015.00071/full, doi: 10.3389/fped.2015.00071
  • Subject: Pulmonary vascular remodeling | RJ1-570 | endothelial progenitor cells | pulmonary hypertension | Pediatrics | right ventricular dysfunction | Heme Oxygenase-1 | Neointimal Hyperplasia
    mesheuropmc: cardiovascular system

BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts through mobiliz... View more
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