publication . Article . 2017

Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia.

Rui Lu; Rui Lu; Gang Greg Wang; Gang Greg Wang;
Open Access English
  • Published: 01 Oct 2017 Journal: Frontiers in Oncology (issn: 2234-943X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Acute myeloid leukemia (AML), a common hematological cancer of myeloid lineage cells, generally exhibits poor prognosis in the clinic and demands new treatment options. Recently, direct sequencing of samples from human AMLs and pre-leukemic diseases has unveiled their mutational landscapes and significantly advanced the molecular understanding of AML pathogenesis. The newly identified recurrent mutations frequently “hit” genes encoding epigenetic modulators, a wide range of chromatin-modifying enzymes and regulatory factors involved in gene expression regulation, supporting aberration of chromatin structure and epigenetic modification as a main oncogenic mechani...
Subjects
Medical Subject Headings: hemic and lymphatic diseases
free text keywords: epigenetic modulator, small-molecule inhibitors, acute myeloid leukemia, bromodomain, MLL, EZH2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Mini Review, DNMT3A, Cancer Research, Oncology, Biology, DOT1L, Histone methyltransferase, Chromatin, Chromatin remodeling, KMT2A, biology.protein, Epigenetics, Myeloid leukemia, Demethylase
Funded by
NIH| Cancer Epigenetics: A novel PRC2 Dysregulation Mechanism in Multiple Myeloma
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA211336-02
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Determining the Role of DNA Methylation Deregulation in Oncogenesis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01CA215284-01
  • Funding stream: NATIONAL CANCER INSTITUTE
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