publication . Other literature type . Article . 2019

miR-21: a promising biomarker for the early detection of colon cancer

Farnaz Dehghan; Sohrab Boozarpour; Zhila Torabizadeh; Sakineh Alijanpour;
  • Published: 01 Jul 2019
  • Publisher: Informa UK Limited
Abstract
Farnaz Dehghan,1 Sohrab Boozarpour,1 Zhila Torabizadeh,2 Sakineh Alijanpour11Department of Biology, Faculty of Basic Sciences, Gonbad kavous University, Gonbad kavous, Golestan, Iran; 2Department of Medical Pathology, Faculty of Medicine, Sari University of Medical Sciences, Sari, Mazandaran, IranPurpose: The aim of this study was to compare the expression of miR-21 gene in stages II-IV of formalin-fixed paraffin-embedded (FFPE) tissue in patients with colon cancer and introduce miR-21 as a potential molecular marker for detection of colon cancer in the early stages.Introduction: Currently, identification of key molecules involved in the pathogenesis of cancer i...
Subjects
free text keywords: OncoTargets and Therapy, Original Research, colon cancer, pathological stages, miR-21, gene expression, biomarker, early diagnosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Pharmacology (medical), Oncology, Pathology, medicine.medical_specialty, medicine, Gene, Colorectal cancer, medicine.disease, Cancer research, business.industry, business, Biomarker (medicine), Molecular marker, chemistry.chemical_compound, chemistry, Early detection
Related Organizations
42 references, page 1 of 3

1. Houlston RS, Tomlinson IP. Polymorphisms and colorectal tumor risk. Gastroenterology. 2001;121(2):282-301.

2. Moertel CG, Fleming TR, Macdonald JS, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990;322(6):352-358. doi:10.1056/NEJM19900208322 0602 [OpenAIRE]

3. Kim M, Kasinski AL, Slack FJ. MicroRNA therapeutics in preclinical cancer models. Lancet Oncol. 2011;12(4):319-321. doi:10.1016/ S1470-2045(11)70067-5 [OpenAIRE]

4. Schaefer A, Jung M, Kristiansen G, et al. MicroRNAs and cancer: current state and future perspectives in urologic oncology. Urol Oncol. 2010;28(1):4-13. doi:10.1016/j.urolonc.2008.10.021

5. Kozomara A, Griffiths-Jones S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014;42 (Database issue):D68-73. doi:10.1093/nar/gkt1181 [OpenAIRE]

6. Wouters MD, van Gent DC, Hoeijmakers JH, Pothof J. MicroRNAs, the DNA damage response and cancer. Mutat Res. 2011;717(1- 2):54-66. doi:10.1016/j.mrfmmm.2011.03.012

7. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92-105. doi:10.1101/gr.082701.108

8. Babashah S, Soleimani M. The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis. Eur J Cancer. 2011;47 (8):1127-1137. doi:10.1016/j.ejca.2011.02.008 [OpenAIRE]

9. Kanellopoulou C, Monticelli S. A role for microRNAs in the development of the immune system and in the pathogenesis of cancer. Semin Cancer Biol. 2008;18(2):79-88. doi:10.1016/j.semcancer. 2008.01.002 [OpenAIRE]

10. Lu Z, Liu M, Stribinskis V, et al. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene. 2008;27(31):4373-4379. doi:10.1038/onc.2008.72 [OpenAIRE]

11. Fujita S, Ito T, Mizutani T, et al. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008;378(3):492-504. doi:10.1016/j.jmb.2008.03.015

12. Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28(17):5369-5380. doi:10.1128/MCB.00479-08 [OpenAIRE]

13. Pezzolesi MG, Platzer P, Waite KA, Eng C. Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. Am J Hum Genet. 2008;82(5):1141-1149. doi:10.1016/j. ajhg.2008.04.005 [OpenAIRE]

14. Bovell LC, Shanmugam C, Putcha BD, et al. The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer. Clin Cancer Res. 2013;19(14):3955-3965. doi:10.1158/1078- 0432.CCR-12-3302 [OpenAIRE]

15. Hatley ME, Patrick DM, Garcia MR, et al. Modulation of K-Rasdependent lung tumorigenesis by microRNA-21. Cancer Cell. 2010;18(3):282-293. doi:10.1016/j.ccr.2010.08.013 [OpenAIRE]

42 references, page 1 of 3
Related research
Abstract
Farnaz Dehghan,1 Sohrab Boozarpour,1 Zhila Torabizadeh,2 Sakineh Alijanpour11Department of Biology, Faculty of Basic Sciences, Gonbad kavous University, Gonbad kavous, Golestan, Iran; 2Department of Medical Pathology, Faculty of Medicine, Sari University of Medical Sciences, Sari, Mazandaran, IranPurpose: The aim of this study was to compare the expression of miR-21 gene in stages II-IV of formalin-fixed paraffin-embedded (FFPE) tissue in patients with colon cancer and introduce miR-21 as a potential molecular marker for detection of colon cancer in the early stages.Introduction: Currently, identification of key molecules involved in the pathogenesis of cancer i...
Subjects
free text keywords: OncoTargets and Therapy, Original Research, colon cancer, pathological stages, miR-21, gene expression, biomarker, early diagnosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Pharmacology (medical), Oncology, Pathology, medicine.medical_specialty, medicine, Gene, Colorectal cancer, medicine.disease, Cancer research, business.industry, business, Biomarker (medicine), Molecular marker, chemistry.chemical_compound, chemistry, Early detection
Related Organizations
42 references, page 1 of 3

1. Houlston RS, Tomlinson IP. Polymorphisms and colorectal tumor risk. Gastroenterology. 2001;121(2):282-301.

2. Moertel CG, Fleming TR, Macdonald JS, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990;322(6):352-358. doi:10.1056/NEJM19900208322 0602 [OpenAIRE]

3. Kim M, Kasinski AL, Slack FJ. MicroRNA therapeutics in preclinical cancer models. Lancet Oncol. 2011;12(4):319-321. doi:10.1016/ S1470-2045(11)70067-5 [OpenAIRE]

4. Schaefer A, Jung M, Kristiansen G, et al. MicroRNAs and cancer: current state and future perspectives in urologic oncology. Urol Oncol. 2010;28(1):4-13. doi:10.1016/j.urolonc.2008.10.021

5. Kozomara A, Griffiths-Jones S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014;42 (Database issue):D68-73. doi:10.1093/nar/gkt1181 [OpenAIRE]

6. Wouters MD, van Gent DC, Hoeijmakers JH, Pothof J. MicroRNAs, the DNA damage response and cancer. Mutat Res. 2011;717(1- 2):54-66. doi:10.1016/j.mrfmmm.2011.03.012

7. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92-105. doi:10.1101/gr.082701.108

8. Babashah S, Soleimani M. The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis. Eur J Cancer. 2011;47 (8):1127-1137. doi:10.1016/j.ejca.2011.02.008 [OpenAIRE]

9. Kanellopoulou C, Monticelli S. A role for microRNAs in the development of the immune system and in the pathogenesis of cancer. Semin Cancer Biol. 2008;18(2):79-88. doi:10.1016/j.semcancer. 2008.01.002 [OpenAIRE]

10. Lu Z, Liu M, Stribinskis V, et al. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene. 2008;27(31):4373-4379. doi:10.1038/onc.2008.72 [OpenAIRE]

11. Fujita S, Ito T, Mizutani T, et al. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008;378(3):492-504. doi:10.1016/j.jmb.2008.03.015

12. Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28(17):5369-5380. doi:10.1128/MCB.00479-08 [OpenAIRE]

13. Pezzolesi MG, Platzer P, Waite KA, Eng C. Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. Am J Hum Genet. 2008;82(5):1141-1149. doi:10.1016/j. ajhg.2008.04.005 [OpenAIRE]

14. Bovell LC, Shanmugam C, Putcha BD, et al. The prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal cancer. Clin Cancer Res. 2013;19(14):3955-3965. doi:10.1158/1078- 0432.CCR-12-3302 [OpenAIRE]

15. Hatley ME, Patrick DM, Garcia MR, et al. Modulation of K-Rasdependent lung tumorigenesis by microRNA-21. Cancer Cell. 2010;18(3):282-293. doi:10.1016/j.ccr.2010.08.013 [OpenAIRE]

42 references, page 1 of 3
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