publication . Article . 2015

Combined therapeutic effect and molecular mechanisms of metformin and cisplatin in human lung cancer xenografts in nude mice.

Gang Chen; Yu-Qin Chen;
Open Access English
  • Published: 01 Jan 2015 Journal: Journal of Cancer Research and Therapeutics (issn: 0973-1482, eissn: 1998-4138, Copyright policy)
  • Publisher: Wolters Kluwer Medknow Publications
Abstract
Objective: This work was aimed at studying the inhibitory activity of metformin combined with the commonly used chemotherapy drug cisplatin in human lung cancer xenografts in nude mice. We also examined the combined effects of these drugs on the molecular expression of survivin, matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor-C (VEGF-C), and vascular endothelial growth factorreceptor-3 (VEGFR-3) to determine the mechanism of action and to explore the potential applications of the new effective drug therapy in lung cancer. Materials and Methods: The nude mice model of lung cancer xenografts was established, and mice were randomly divided in...
Subjects
free text keywords: Cisplatin, lung cancer, matrix metalloproteinase-2, metformin, survivin, vascular endothelial growth factor -C, vascular endothelial growth factor receptor-3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, medicine.drug, medicine, Pharmacology, Vascular endothelial growth factor C, Immunohistochemistry, business.industry, business, Mechanism of action, medicine.symptom, medicine.disease, Reverse transcription polymerase chain reaction
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publication . Article . 2015

Combined therapeutic effect and molecular mechanisms of metformin and cisplatin in human lung cancer xenografts in nude mice.

Gang Chen; Yu-Qin Chen;