publication . Article . Other literature type . 2018

Calcium and Nuclear Signaling in Prostate Cancer.

Wilma Hofmann;
Open Access
  • Published: 19 Apr 2018 Journal: International Journal of Molecular Sciences, volume 19, page 1,237 (eissn: 1422-0067, Copyright policy)
  • Publisher: MDPI AG
Abstract
Recently, there have been a number of developments in the fields of calcium and nuclear signaling that point to new avenues for a more effective diagnosis and treatment of prostate cancer. An example is the discovery of new classes of molecules involved in calcium-regulated nuclear import and nuclear calcium signaling, from the G protein-coupled receptor (GPCR) and myosin families. This review surveys the new state of the calcium and nuclear signaling fields with the aim of identifying the unifying themes that hold out promise in the context of the problems presented by prostate cancer. Genomic perturbations, kinase cascades, developmental pathways, and channels...
Subjects
free text keywords: Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Spectroscopy, Molecular Biology, Catalysis, General Medicine, Computer Science Applications, Review, metastasis, nuclear import, myosin IC, calcium, prostate cancer, Biology (General), QH301-705.5, Chemistry, QD1-999
210 references, page 1 of 14

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Carlsson, S., Vickers, A.. Spotlight on prostate cancer: The latest evidence and current controversies. BMC Med.. 2015; 13 [OpenAIRE] [PubMed] [DOI]

Shen, M.M., Abate-Shen, C.. Molecular genetics of prostate cancer: New prospects for old challenges. Genes Dev.. 2010; 24: 1967-2000 [OpenAIRE] [PubMed] [DOI]

Bootman, M.D.. Calcium signaling. Cold Spring Harb. Perspect. Biol.. 2012; 4: a011171 [OpenAIRE] [PubMed] [DOI]

Cautain, B., Hill, R., de Pedro, N., Link, W.. Components and regulation of nuclear transport processes. FEBS J.. 2015; 282: 445-462 [OpenAIRE] [PubMed] [DOI]

Godfraind, T.. Discovery and Development of Calcium Channel Blockers. Front. Pharmacol.. 2017; 8: 286 [OpenAIRE] [PubMed] [DOI]

Cui, C., Merritt, R., Fu, L., Pan, Z.. Targeting calcium signaling in cancer therapy. Acta Pharm. Sin. B. 2017; 7: 3-17 [OpenAIRE] [PubMed] [DOI]

Hauser, A.S., Attwood, M.M., Rask-Andersen, M., Schioth, H.B., Gloriam, D.E.. Trends in GPCR drug discovery: New agents, targets and indications. Nat. Rev. Drug Discov.. 2017; 16: 829-842 [OpenAIRE] [PubMed] [DOI]

Ouderkirk, J.L., Krendel, M.. Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis. Cytoskeleton. 2014; 71: 447-463 [OpenAIRE] [PubMed] [DOI]

Li, Y.R., Yang, W.X.. Myosins as fundamental components during tumorigenesis: Diverse and indispensable. Oncotarget. 2016; 7: 46785-46812 [OpenAIRE] [PubMed] [DOI]

Maly, I.V., Hofmann, W.A.. Calcium-regulated import of myosin IC into the nucleus. Cytoskeleton. 2016; 73: 341-350 [OpenAIRE] [PubMed] [DOI]

Don-Salu-Hewage, A.S., Chan, S.Y., McAndrews, K.M., Chetram, M.A., Dawson, M.R., Bethea, D.A., Hinton, C.V.. Cysteine (C)-X-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS ONE. 2013; 8 [OpenAIRE] [PubMed] [DOI]

Emmert-Buck, M.R., Vocke, C.D., Pozzatti, R.O., Duray, P.H., Jennings, S.B., Florence, C.D., Zhuang, Z., Bostwick, D.G., Liotta, L.A., Linehan, W.M.. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res.. 1995; 55: 2959-2962 [PubMed]

Bethel, C.R., Faith, D., Li, X., Guan, B., Hicks, J.L., Lan, F., Jenkins, R.B., Bieberich, C.J., De Marzo, A.M.. Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: Association with gleason score and chromosome 8p deletion. Cancer Res.. 2006; 66: 10683-10690 [OpenAIRE] [PubMed] [DOI]

210 references, page 1 of 14
Abstract
Recently, there have been a number of developments in the fields of calcium and nuclear signaling that point to new avenues for a more effective diagnosis and treatment of prostate cancer. An example is the discovery of new classes of molecules involved in calcium-regulated nuclear import and nuclear calcium signaling, from the G protein-coupled receptor (GPCR) and myosin families. This review surveys the new state of the calcium and nuclear signaling fields with the aim of identifying the unifying themes that hold out promise in the context of the problems presented by prostate cancer. Genomic perturbations, kinase cascades, developmental pathways, and channels...
Subjects
free text keywords: Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Spectroscopy, Molecular Biology, Catalysis, General Medicine, Computer Science Applications, Review, metastasis, nuclear import, myosin IC, calcium, prostate cancer, Biology (General), QH301-705.5, Chemistry, QD1-999
210 references, page 1 of 14

Miller, K.D., Siegel, R.L., Lin, C.C., Mariotto, A.B., Kramer, J.L., Rowland, J.H., Stein, K.D., Alteri, R., Jemal, A.. Cancer treatment and survivorship statistics, 2016. CA Cancer J. Clin.. 2016; 66: 271-289 [OpenAIRE] [PubMed] [DOI]

Siegel, R.L., Miller, K.D., Jemal, A.. Cancer statistics, 2016. CA Cancer J. Clin.. 2016; 66: 7-30 [OpenAIRE] [PubMed] [DOI]

Carlsson, S., Vickers, A.. Spotlight on prostate cancer: The latest evidence and current controversies. BMC Med.. 2015; 13 [OpenAIRE] [PubMed] [DOI]

Shen, M.M., Abate-Shen, C.. Molecular genetics of prostate cancer: New prospects for old challenges. Genes Dev.. 2010; 24: 1967-2000 [OpenAIRE] [PubMed] [DOI]

Bootman, M.D.. Calcium signaling. Cold Spring Harb. Perspect. Biol.. 2012; 4: a011171 [OpenAIRE] [PubMed] [DOI]

Cautain, B., Hill, R., de Pedro, N., Link, W.. Components and regulation of nuclear transport processes. FEBS J.. 2015; 282: 445-462 [OpenAIRE] [PubMed] [DOI]

Godfraind, T.. Discovery and Development of Calcium Channel Blockers. Front. Pharmacol.. 2017; 8: 286 [OpenAIRE] [PubMed] [DOI]

Cui, C., Merritt, R., Fu, L., Pan, Z.. Targeting calcium signaling in cancer therapy. Acta Pharm. Sin. B. 2017; 7: 3-17 [OpenAIRE] [PubMed] [DOI]

Hauser, A.S., Attwood, M.M., Rask-Andersen, M., Schioth, H.B., Gloriam, D.E.. Trends in GPCR drug discovery: New agents, targets and indications. Nat. Rev. Drug Discov.. 2017; 16: 829-842 [OpenAIRE] [PubMed] [DOI]

Ouderkirk, J.L., Krendel, M.. Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis. Cytoskeleton. 2014; 71: 447-463 [OpenAIRE] [PubMed] [DOI]

Li, Y.R., Yang, W.X.. Myosins as fundamental components during tumorigenesis: Diverse and indispensable. Oncotarget. 2016; 7: 46785-46812 [OpenAIRE] [PubMed] [DOI]

Maly, I.V., Hofmann, W.A.. Calcium-regulated import of myosin IC into the nucleus. Cytoskeleton. 2016; 73: 341-350 [OpenAIRE] [PubMed] [DOI]

Don-Salu-Hewage, A.S., Chan, S.Y., McAndrews, K.M., Chetram, M.A., Dawson, M.R., Bethea, D.A., Hinton, C.V.. Cysteine (C)-X-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS ONE. 2013; 8 [OpenAIRE] [PubMed] [DOI]

Emmert-Buck, M.R., Vocke, C.D., Pozzatti, R.O., Duray, P.H., Jennings, S.B., Florence, C.D., Zhuang, Z., Bostwick, D.G., Liotta, L.A., Linehan, W.M.. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res.. 1995; 55: 2959-2962 [PubMed]

Bethel, C.R., Faith, D., Li, X., Guan, B., Hicks, J.L., Lan, F., Jenkins, R.B., Bieberich, C.J., De Marzo, A.M.. Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: Association with gleason score and chromosome 8p deletion. Cancer Res.. 2006; 66: 10683-10690 [OpenAIRE] [PubMed] [DOI]

210 references, page 1 of 14
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