publication . Article . 2016

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Angus W. Thomson; Alan F. Zahorchak; Mohamed B. Ezzelarab; Lisa H. Butterfield; Fadi G. Lakkis; Diana M. Metes;
Open Access English
  • Published: 28 Jan 2016 Journal: Frontiers in Immunology, volume 7 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under a variety of conditions. Here, we provide a rationale for evaluation of DCreg therapy in clinical organ transplantation with the goal of promoting sustained, donor-specific hyporesponsiveness, while lowering the incidence and severity of rejection and reducing patients’ dependence on anti-rejection drugs. Generation of donor- or recipient-derived DCreg that suppress T cell resp...
Subjects
free text keywords: Immunology, Review, dendritic cells, immune regulation, renal transplantation, cell therapy, immune monitoring, Immunologic diseases. Allergy, RC581-607, Immune system, Good manufacturing practice, T cell, medicine.anatomical_structure, medicine, Immunosuppression, medicine.medical_treatment, Organ transplantation, medicine.medical_specialty, Subclinical infection, business.industry, business
Funded by
NIH| CANCER CENTER SUPPORT GRANT
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30CA047904-07S1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Contribution of TFH and of TREG cells to DSA generation in sensitized KTx recipients
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R21AI116746-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| University of Pittsburgh Clinical and Translational Science Institute
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8UL1TR000005-07
  • Funding stream: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
110 references, page 1 of 8

1 Meier-Kriesche HU Schold JD Kaplan B. Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am J Transplant (2004) 4:1289–95.10.1111/j.1600-6143.2004.00515.x 15268730 [OpenAIRE] [PubMed] [DOI]

2 Lamb KE Lodhi S Meier-Kriesche HU. Long-term renal allograft survival in the United States: a critical reappraisal. Am J Transplant (2011) 11:450–62.10.1111/j.1600-6143.2010.03283.x 20973913 [OpenAIRE] [PubMed] [DOI]

3 Vincenti F Charpentier B Vanrenterghem Y Rostaing L Bresnahan B Darji P A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant (2010) 10:535–46.10.1111/j.1600-6143.20 09.03005.x 20415897 [OpenAIRE] [PubMed] [DOI]

4 Hricik DE Formica RN Nickerson P Rush D Fairchild RL Poggio ED Adverse outcomes of tacrolimus withdrawal in immune-quiescent kidney transplant recipients. J Am Soc Nephrol (2015) 26:3114–22.10.1681/ASN.2014121234 25925687 [OpenAIRE] [PubMed] [DOI]

5 Ekberg H Tedesco-Silva H Demirbas A Vitko S Nashan B Gurkan A Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med (2007) 357:2562–75.10.1056/NEJMoa067411 18094377 [PubMed] [DOI]

6 Billingham RE Brent L Medawar PB. Actively acquired tolerance of foreign cells. Nature (1953) 172:603–6.10.1038/172603a0 [OpenAIRE] [DOI]

7 Kawai T Leventhal J Madsen JC Strober S Turka LA Wood KJ. Tolerance: one transplant for life. Transplantation (2014) 98:117–21.10.1097/TP.0000000000000260 24926829 [OpenAIRE] [PubMed] [DOI]

8 Ohnmacht C Pullner A King SB Drexler I Meier S Brocker T Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med (2009) 206:549–59.10.1084/jem.2 0082394 19237601 [OpenAIRE] [PubMed] [DOI]

9 Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol (2004) 22:531–62.10.1146/annurev.immunol.21.120601.141122 15032588 [OpenAIRE] [PubMed] [DOI]

10 Beriou G Peche H Guillonneau C Merieau E Cuturi MC. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation (2005) 79:969–72.10.1097/01.TP.0000158277.50073.35 15849552 [PubMed] [DOI]

11 Hill M Thebault P Segovia M Louvet C Beriou G Tilly G Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3. Am J Transplant (2011) 11:2036–45.10.1111/j.1600-6143.2011.03651.x 21794083 [OpenAIRE] [PubMed] [DOI]

12 Lutz MB Suri RM Niimi M Ogilvie AL Kukutsch NA Rossner S Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol (2000) 30:1813–22.10.1002/1521-4141(200007)30:7<1813::AID-IMMU1813>3.0.CO;2-8 10940870 [OpenAIRE] [PubMed] [DOI]

13 Morelli AE Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol (2007) 7:610–21.10.1038/nri2132 17627284 [OpenAIRE] [PubMed] [DOI]

14 Kingsley C Karim M Bushell A Wood K. CD25+CD4+ regulatory T cells prevent graft rejection:CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol (2002) 168:1080–6.10.4049/jimmunol.168.3.1080 11801641 [OpenAIRE] [PubMed] [DOI]

15 Wood KJ Bushell A Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol (2012) 12:417–30.10.1038/nri3227 22627860 [OpenAIRE] [PubMed] [DOI]

110 references, page 1 of 8
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue