publication . Article . 2016

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Angus W. Thomson; Alan F. Zahorchak; Mohamed B. Ezzelarab; Lisa H. Butterfield; Fadi G. Lakkis; Diana M. Metes;
Open Access English
  • Published: 28 Jan 2016 Journal: Frontiers in Immunology, volume 7 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under a variety of conditions. Here, we provide a rationale for evaluation of DCreg therapy in clinical organ transplantation with the goal of promoting sustained, donor-specific hyporesponsiveness, while lowering the incidence and severity of rejection and reducing patients’ dependence on anti-rejection drugs. Generation of donor- or recipient-derived DCreg that suppress T cell resp...
free text keywords: Immunology, Review, dendritic cells, immune regulation, renal transplantation, cell therapy, immune monitoring, Immunologic diseases. Allergy, RC581-607, Immune system, Good manufacturing practice, T cell, medicine.anatomical_structure, medicine, Immunosuppression, medicine.medical_treatment, Organ transplantation, medicine.medical_specialty, Subclinical infection, business.industry, business
Funded by
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P30CA047904-07S1
NIH| Contribution of TFH and of TREG cells to DSA generation in sensitized KTx recipients
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R21AI116746-01
NIH| University of Pittsburgh Clinical and Translational Science Institute
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8UL1TR000005-07
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