publication . Article . 2003

Effects of Metalloporphyrins on Heme Oxygenase-1 Transcription: Correlative Cell Culture Assays Guide In Vivo Imaging

Christopher H. Contag; Ronald J. Wong; David K. Stevenson; Weisheng Zhang; Hendrik J. Vreman; Monica Hajdena-Dawson; Pamela R. Contag;
Open Access
  • Published: 01 Jul 2003 Journal: Molecular Imaging, volume 2, page 153,535,002,003,031 (issn: 1536-0121, eissn: 1536-0121, Copyright policy)
  • Publisher: SAGE Publications
Abstract
Heme oxygenase (HO) is the rate-limiting step in the heme degradation pathway and is a potential target for the control, or prevention, of pathologic jaundice in neonates. Metalloporphyrins (Mps), a diverse set of synthetic derivatives of heme, can competitively inhibit the HO enzymes. However, certain Mps are phototoxic and some increase transcription of HO-1, the inducible HO isozyme. Therefore, effective development of this class of compounds as therapeutics for treating pathologic jaundice will require rapid and integrated biological screens to identify the most efficacious and safe Mps. To study the safety of these compounds, we assessed their cytotoxic eff...
Subjects
free text keywords: Biotechnology, Molecular Medicine, Radiology Nuclear Medicine and imaging, Condensed Matter Physics, Biomedical Engineering, Biology (General), QH301-705.5, Heme, chemistry.chemical_compound, chemistry, Cytotoxicity, Heme oxygenase, In vivo, Cell culture assays, Biochemistry, Zinc protoporphyrin, Biology, Cell culture, Viability assay
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