publication . Article . 2017

Conservation of Three-Dimensional Helix-Loop-Helix Structure through the Vertebrate Lineage Reopens the Cold Case of Gonadotropin-Releasing Hormone-Associated Peptide.

Daniela I. Pérez Sirkin; Daniela I. Pérez Sirkin; Anne-Gaëlle Lafont; Nédia Kamech; Gustavo M. Somoza; Paula G. Vissio; Paula G. Vissio; Sylvie Dufour;
Open Access English
  • Published: 01 Aug 2017 Journal: Frontiers in Endocrinology (issn: 1664-2392, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
GnRH-associated peptide (GAP) is the C-terminal portion of the gonadotropin-releasing hormone (GnRH) preprohormone. Although it was reported in mammals that GAP may act as a prolactin-inhibiting factor and can be co-secreted with GnRH into the hypophyseal portal blood, GAP has been practically out of the research circuit for about 20 years. Comparative studies highlighted the low conservation of GAP primary amino acid sequences among vertebrates, contributing to consider that this peptide only participates in the folding or carrying process of GnRH. Considering that the three-dimensional (3D) structure of a protein may define its function, the aim of this study ...
Subjects
free text keywords: Otras Ciencias Biológicas, Ciencias Biológicas, CIENCIAS NATURALES Y EXACTAS, GnRH-associated peptide, protein 3D structure, helix-loop-helix, phylogeny, evolution, vertebrates, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, teleosts, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Original Research, Amino acid, chemistry.chemical_classification, chemistry, Basic helix-loop-helix, Phylogenetics, Peptide sequence, Endocrinology, medicine.medical_specialty, medicine, Bioinformatics, Preprohormone, Molecular phylogenetics, Evolutionary biology, Peptide, Vertebrate, biology.animal, biology, Internal medicine
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publication . Article . 2017

Conservation of Three-Dimensional Helix-Loop-Helix Structure through the Vertebrate Lineage Reopens the Cold Case of Gonadotropin-Releasing Hormone-Associated Peptide.

Daniela I. Pérez Sirkin; Daniela I. Pérez Sirkin; Anne-Gaëlle Lafont; Nédia Kamech; Gustavo M. Somoza; Paula G. Vissio; Paula G. Vissio; Sylvie Dufour;