Conservation of Three-Dimensional Helix-Loop-Helix Structure through the Vertebrate Lineage Reopens the Cold Case of Gonadotropin-Releasing Hormone-Associated Peptide

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Daniela I. Pérez Sirkin ; Daniela I. Pérez Sirkin ; Anne-Gaëlle Lafont ; Nédia Kamech ; Gustavo M. Somoza ; Paula G. Vissio ; Paula G. Vissio ; Sylvie Dufour (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Endocrinology (issn: 1664-2392)
  • Related identifiers: doi: 10.3389/fendo.2017.00207/full, doi: 10.3389/fendo.2017.00207
  • Subject: protein 3D structure | RC648-665 | helix-loop-helix | phylogeny | Diseases of the endocrine glands. Clinical endocrinology | evolution | GnRH-associated peptide | vertebrates
    mesheuropmc: endocrine system | hormones, hormone substitutes, and hormone antagonists

GnRH-associated peptide (GAP) is the C-terminal portion of the gonadotropin-releasing hormone (GnRH) preprohormone. Although it was reported in mammals that GAP may act as a prolactin-inhibiting factor and can be co-secreted with GnRH into the hypophyseal portal blood, ... View more
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