publication . Article . 2018

Chronic Manganese Toxicity Associated with Voltage-Gated Potassium Channel Complex Antibodies in a Relapsing Neuropsychiatric Disorder

Roger Ho; Cyrus SH Ho;
Open Access English
  • Published: 01 Apr 2018 Journal: International Journal of Environmental Research and Public Health, volume 15, issue 4 (issn: 1661-7827, eissn: 1660-4601, Copyright policy)
  • Publisher: MDPI
Abstract
Heavy metal poisoning is a rare but important cause of encephalopathy. Manganese (Mn) toxicity is especially rare in the modern world, and clinicians’ lack of recognition of its neuropsychiatric manifestations can lead to misdiagnosis and mismanagement. We describe the case of a man who presented with recurrent episodes of confusion, psychosis, dystonic limb movement and cognitive impairment and was initially diagnosed with anti-voltage-gated potassium channel (VGKC) complex limbic encephalitis in view of previous positive autoantibodies. His failure to respond to immunotherapy prompted testing for heavy metal poisoning, which was positive for Mn. This is ...
Subjects
free text keywords: Case Report, manganese toxicity, voltage-gated potassium channel complex antibodies, neuropsychiatric disorder, Medicine, R
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