publication . Article . 2014

RELATIONSHIP BETWEEN CD34/CD45 POSITIVE CELLS CONCENTRATION IN BLOOD OF HEART RECIPIENTS AND LEVEL OF GRAFT VASCULOPATHY RISK BIOMARKERS

O. P. Shevchenko; R. M. Kurabekova; E. V. Naumova; S. A. Lugovskaya; E. A. Spirina; V. N. Poptsov; G. A. Olefirenko; V. V. Dolgov;
Open Access Russian
  • Published: 16 May 2014 Journal: Vestnik Transplantologii i Iskusstvennyh Organov (issn: 1995-1191, Copyright policy)
  • Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Abstract
Aim. To determine the relationship between CD34/CD45 positive cells number in peripheral blood before and after heart transplantation (HTx) and plasma level of the biomarkers. Materials and methods. We studied 27 pts. (23 men; 40 ± 13 years) with heart failure caused by dilated (17 cases) or ischemic cardiomyopathy (10 cases) before and after HTx. CD34/CD45 positive cells were measured in peripheral blood before and 2–4 days after the operation by fl ow cytometry and expressed in number of the cells per 10 6 events, plasma level of the biomar- kers – by ELISA. Results. The number of CD34/CD45+ cells in pts. with heart failure (224 ± 166) was similar to those in ...
Subjects
free text keywords: hematopoietic stem cells, biomarkers, heart transplantation, Surgery, RD1-811, Cardiology, medicine.medical_specialty, medicine, Transplantation, Heart failure, medicine.disease, CD34, Diabetes mellitus, Ischemic cardiomyopathy, Hypothermia, medicine.symptom, business.industry, business, Ischemia, medicine.medical_treatment, Internal medicine
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