publication . Article . Other literature type . 2019

BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells

Machado, Ana Rita Thomazela; Aissa, Alexandre Ferro; Ribeiro, Diego Luis; Ferreira Jr., Rui Seabra; Sampaio, Suely Vilela; Antunes, Lusânia Maria Greggi;
Open Access English
  • Published: 01 Mar 2019 Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases, volume 25 (issn: 1678-9199, eissn: 1678-9199, Copyright policy)
  • Publisher: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
Abstract
Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carcinoma has increased worldwide, and the aberrant DNA methylation of liver cells is a common mechanism to promote hepatic tumorigenesis. Moreover, tumor microenvironment plays a major role in neoplastic transformation. To elucidate the molecular mechanisms responsible for the cytotoxic effects of SV-LAAO in hum...
Subjects
free text keywords: GADD45A, RC955-962, Toxicology. Poisons, CDKN1A, snake venom, QL1-991, CCND1, RA1190-1270, Arctic medicine. Tropical medicine, epigenetics, Zoology, Research
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publication . Article . Other literature type . 2019

BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells

Machado, Ana Rita Thomazela; Aissa, Alexandre Ferro; Ribeiro, Diego Luis; Ferreira Jr., Rui Seabra; Sampaio, Suely Vilela; Antunes, Lusânia Maria Greggi;