BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells

Article English OPEN
Ana Rita Thomazela Machado; Alexandre Ferro Aissa; Diego Luis Ribeiro; Rui Seabra Ferreira Jr.; Suely Vilela Sampaio; Lusânia Maria Greggi Antunes;
  • Publisher: BMC
  • Journal: Journal of Venomous Animals and Toxins including Tropical Diseases (issn: 1678-9199)
  • Related identifiers: doi: 10.1590/1678-9199-jvatitd-1476-18
  • Subject: GADD45A | RC955-962 | Toxicology. Poisons | CDKN1A | snake venom | QL1-991 | CCND1 | RA1190-1270 | Arctic medicine. Tropical medicine | epigenetics | Zoology

Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological... View more
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