Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade

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Mohamed B. Ezzelarab; Lien Lu; William F. Shufesky; Adrian E. Morelli; Adrian E. Morelli; Angus W. Thomson; Angus W. Thomson;

(2018)

Publisher: Frontiers Media S.A.

Journal: Frontiers in Immunology (issn: 1664-3224)

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Identifiers: doi: 10.3389/fimmu.2018.00250, doi: 10.3389/fimmu.2018.00250/full
Subject: regulatory T cells | dendritic cells | co-stimulation blockade | renal allografts | non-human primates | Immunologic diseases. Allergy | RC581-607

Donor-derived regulatory dendritic cell (DCreg) infusion before transplantation, significantly prolongs renal allograft survival in non-human primates. This is associated with enhanced expression of the immunoregulatory molecules cytotoxic T-lymphocyte-associated antige... View more

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