Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade

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Mohamed B. Ezzelarab; Lien Lu; William F. Shufesky; Adrian E. Morelli; Adrian E. Morelli; Angus W. Thomson; Angus W. Thomson;
(2018)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology (issn: 1664-3224)
  • Related identifiers: doi: 10.3389/fimmu.2018.00250, doi: 10.3389/fimmu.2018.00250/full
  • Subject: regulatory T cells | dendritic cells | co-stimulation blockade | renal allografts | non-human primates | Immunologic diseases. Allergy | RC581-607

Donor-derived regulatory dendritic cell (DCreg) infusion before transplantation, significantly prolongs renal allograft survival in non-human primates. This is associated with enhanced expression of the immunoregulatory molecules cytotoxic T-lymphocyte-associated antige... View more
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