publication . Article . 2018

Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.

Mohamed B. Ezzelarab; Lien Lu; William F. Shufesky; Adrian E. Morelli; Adrian E. Morelli; Angus W. Thomson; Angus W. Thomson;
Open Access
  • Published: 01 Feb 2018 Journal: Frontiers in Immunology, volume 9 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Donor-derived regulatory dendritic cell (DCreg) infusion before transplantation, significantly prolongs renal allograft survival in non-human primates. This is associated with enhanced expression of the immunoregulatory molecules cytotoxic T-lymphocyte-associated antigen (Ag) 4 (CTLA4) and programmed cell death protein 1 (PD1) by host donor-reactive T cells. In rodents and humans, CD28 co-stimulatory pathway blockade with the fusion protein CTLA4:Ig (CTLA4Ig) is associated with reduced differentiation and development of regulatory T cells (Treg). We hypothesized that upregulation of CTLA4 by donor-reactive CD4+ T cells in DCreg-infused recipients treated with CT...
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doi: 10.3389/fimmu.2018.00250 , 10.3389/fimmu.2018.00250/full
pmc: PMC5827543
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Subjects
free text keywords: Immunology, Original Research, regulatory T cells, dendritic cells, co-stimulation blockade, renal allografts, non-human primates, Immunologic diseases. Allergy, RC581-607, Chemistry, Transplantation, Endocrinology, medicine.medical_specialty, medicine, T cell, medicine.anatomical_structure, Internal medicine, Antigen, Blockade, Downregulation and upregulation, Dendritic cell, CD28, Cytotoxic T cell
Related Organizations
Funded by
NIH| Rhesus Monkey Dendritic Cells for Transplant Tolerance
Project
Rhesus Monkey Dendritic Cells for Transplant Tolerance
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2U01AI051698-06
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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