publication . Article . 2011

The Application of MRI for Depiction of Subtle Blood Brain Barrier Disruption in Stroke

David Israeli, David Tanne, Dianne Daniels, David Last, Ran Shneor, David Guez, Efrat Landau, Yiftach Roth, Aharon Ocherashvilli, Mati Bakon, Chen Hoffman, Amit Weinberg, Talila Volk, Yael Mardor;
Open Access English
  • Published: 01 Jan 2011 Journal: International Journal of Biological Sciences (issn: 1449-2288, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
<p>The development of imaging methodologies for detecting blood-brain-barrier (BBB) disruption may help predict stroke patient's propensity to develop hemorrhagic complications following reperfusion. We have developed a delayed contrast extravasation MRI-based methodology enabling real-time depiction of subtle BBB abnormalities in humans with high sensitivity to BBB disruption and high spatial resolution. The increased sensitivity to subtle BBB disruption is obtained by acquiring T1-weighted MRI at relatively long delays (&#126;15 minutes) after contrast injection and subtracting from them images acquired immediately after contrast administration. In addition, t...
Subjects
free text keywords: Biology (General), QH301-705.5
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