publication . Article . Other literature type . 2018

Genetic and Virulent Difference Between Pigmented and Non-pigmented Staphylococcus aureus.

Fangning Jin; Dao-Feng Zhang; Jing Zhang; Hang Zhao; Chunlei Shi; Yujuan Suo;
Open Access English
  • Published: 01 Apr 2018 Journal: Frontiers in Microbiology (issn: 1664-302X, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Staphyloxanthin (STX), a golden carotenoid pigment produced by Staphylococcus aureus, is suggested to act as an important virulence factor due to its antioxidant properties. Restraining biosynthesis of STX was considered as an indicator of virulence decline in pigmented S. aureus isolates. However, it is not clear whether natural non-pigmented S. aureus isolates have less virulence than pigmented ones. In this study, it is aimed to compare the pigmented and non-pigmented S. aureus isolates to clarify the genetic and virulent differences between the two groups. Here, 132 S. aureus isolates were divided into two phenotype groups depending on the absorbance (OD450)...
Subjects
Medical Subject Headings: sense organs
free text keywords: Staphylococcus aureus, staphyloxanthin, non-pigmented, virulence, murine sepsis model, Microbiology, QR1-502, Original Research, Microbiology (medical), Multilocus sequence typing, medicine.disease_cause, medicine, Gene, Phenotype, Biology, Virulence factor, Carotenoid, chemistry.chemical_classification, chemistry, chemistry.chemical_compound
Related Organizations
36 references, page 1 of 3

Argudin M. A.Dodemont M.Vandendriessche S.Rottiers S.Tribes C.Roisin S. (2016). Low occurrence of the new species Staphylococcus ar genteus in a Staphylococcus aureus collection of human isolates from Belgium. Eur. J. Clin. Microbiol. Infect. Dis. 35 1017–1022. 10.1007/s10096-016-2632-x 27044019 [OpenAIRE] [PubMed] [DOI]

Becker K.Friedrich A. W.Lubritz G.Weilert M.Peters G.von Eiff C. (2003). Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimens. J. Clin. Microbiol. 41 1434–1439. 10.1128/jcm.41.4.1434-1439.2003 12682126 [OpenAIRE] [PubMed] [DOI]

Cegelski L.Marshall G. R.Eldridge G. R.Hultgren S. J. (2008). The biology and future prospects of antivirulence therapies. Nat. Rev. Micr obiol. 6 17–27. 10.1038/nrmicro1818 18079741 [OpenAIRE] [PubMed] [DOI]

Chen F.Di H.Wang Y.Cao Q.Xu B.Zhang X. (2016). Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence. Nat. Chem. Biol. 12 174–179. 10.1038/nchembio.2003 26780405 [OpenAIRE] [PubMed] [DOI]

Cheung A. L.Bayer A. S.Zhang G.Gresham H.Xiong Y.-Q. (2004). Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol. Med. Microbiol. 40 1–9. 10.1016/S0928-8244(03)00309-2 14734180 [PubMed] [DOI]

Clauditz A.Resch A.Wieland K. P.Peschel A.Gotz F. (2006). Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress. Infect. Immun. 74 4950–4953. 10.1128/iai.00204-06 16861688 [OpenAIRE] [PubMed] [DOI]

Deshmukh H. S.Hamburger J. B.Ahn S. H.McCafferty D. G.Yang S. R.Fowler V. G.Jr. (2009). Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376–1382. 10.1128/IAI.00940-08 19139201 [OpenAIRE] [PubMed] [DOI]

Gao P.Davies J.Kao R. Y. T. (2017). Dehydrosqualene desaturase as a novel target for anti-virulence therapy against Staphylococcus aureus. mBio 8:e1224-17. 10.1128/mBio.01224-17 28874472 [OpenAIRE] [PubMed] [DOI]

George E. A.Novick R. P.Muir T. W. (2008). Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. J. Am. Chem. Soc. 130 4914–1924. 10.1021/ja711126e 18335939 [OpenAIRE] [PubMed] [DOI]

Harmsen D.Claus H.Witte W.Rothganger J.Claus H.Turnwald D. (2003). Typing of me thicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J. Clin. Microbiol. 41 5442–5448. 10.1128/jcm.41.12.5442-5448.2003 14662923 [OpenAIRE] [PubMed] [DOI]

Khodaverdian V.Pesho M.Truitt B.Bollinger L.Patel P.Shoham M. (2010). Discovery of antipathogenic agents against MRSA. Paper Presented at: Interscience Conference on Antimicrobial Agents and Chemotherapy Meeting Boston, MA 12–15.

Kong C.Neoh H. M.Nathan S. (2016). Targeting Staphylococcus aureus toxins: a potential form of anti-virulence therapy. Toxins 8:E72. 10.3390/toxins8030072 26999200 [OpenAIRE] [PubMed] [DOI]

Lan L.Cheng A.Dunman P. M.Missiakas D.He C. (2010). Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus. J. Bacteriol. 192 3068–3077. 10.1128/JB.00928-09 20400547 [OpenAIRE] [PubMed] [DOI]

Lee J. H.Park J. H.Cho M. H.Lee J. (2012). Flavone reduces the production of virulence factors, staphyloxanthin and alpha-hemolysin, in Staphylococcus aureus. Curr. Microbiol. 65 726–732. 10.1007/s00284-012-0229-x 22965624 [OpenAIRE] [PubMed] [DOI]

Lee K.Lee J. H.Kim S. I.Cho M. H.Lee J. (2014). Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl. Microbiol. Biotechnol. 98 9447–9457. 10.1007/s00253-014-5903-4 25027570 [OpenAIRE] [PubMed] [DOI]

36 references, page 1 of 3
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