TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function

Article English OPEN
Mengrui Wu, Yiping Wang, Lianfu Deng, Wei Chen, Yi-Ping Li;
(2012)
  • Publisher: Ivyspring International Publisher
  • Journal: International Journal of Biological Sciences (issn: 1449-2288)
  • Publisher copyright policies & self-archiving
  • Subject: Biology (General) | QH301-705.5
    mesheuropmc: food and beverages | technology, industry, and agriculture | animal diseases | musculoskeletal diseases

<p>Osteoclasts are the principle bone-resorbing cells. Precise control of balanced osteoclast activity is indispensable for bone homeostasis. Osteoclast activation mediated by RANK-TRAF6 axis has been clearly identified. However, a negative regulation-machinery in osteo... View more
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