publication . Article . 2012

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function

Mengrui Wu, Yiping Wang, Lianfu Deng, Wei Chen, Yi-Ping Li;
Open Access English
  • Published: 01 Jan 2012 Journal: International Journal of Biological Sciences (issn: 1449-2288, Copyright policy)
  • Publisher: Ivyspring International Publisher
<p>Osteoclasts are the principle bone-resorbing cells. Precise control of balanced osteoclast activity is indispensable for bone homeostasis. Osteoclast activation mediated by RANK-TRAF6 axis has been clearly identified. However, a negative regulation-machinery in osteoclast remains unclear. TRAF family member-associated NF-&#954;B activator (TANK) is induced by about 10 folds during osteoclastogenesis, according to a genome-wide analysis of gene expression before and after osteoclast maturation, and confirmed by western blot and quantitative RT-PCR. Bone marrow macrophages (BMMs) transduced with lentivirus carrying tank-shRNA were induced to form osteoclast in ...
Medical Subject Headings: food and beveragestechnology, industry, and agriculturemusculoskeletal diseasesanimal diseases
free text keywords: Biology (General), QH301-705.5
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