publication . Article . 2011

FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

Xiang Lin, Yongyou Zhang, Leyuan Liu, Wallace L. McKeehan, Yuemao Shen, Siyang Song, Fen Wang;
Open Access English
  • Published: 01 Jan 2011 Journal: International Journal of Biological Sciences, volume 7, issue 8, pages 1,114-1,121 (issn: 1449-2288, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
<p>Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the <i>Frs2&#945;</i> null mouse embryonic fibroblast (MEF) in conjunction with inhibitors to multiple signaling pathways, here we report that the FGF signaling axis activates mTOR via the FGF receptor substrate 2&#945; (FRS2&#945;)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. In addition, the PI3K/Akt pathway regulated mTOR is crucial for the FGF signaling axis to suppress autophagy...
Subjects
free text keywords: lcsh:Biology (General), lcsh:QH301-705.5
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