publication . Article . 2000

Multiple Cranial Nerve Involvement In Cryptococcal Meningitis

Mahadevan A; Kumar A; Santosh V; Satishchandra P; Shankar S.K;
Open Access English
  • Published: 01 Jan 2000 Journal: Annals of Indian Academy of Neurology (issn: 0972-2327, eissn: 1998-3549, Copyright policy)
  • Publisher: Wolters Kluwer Medknow Publications
Abstract
Cryptococcal meningitis is an uncommon cause of multiple cranial nerve palsies. This case report illustrates one such case of cryptococcal meningitis clinically manifesting with extensive cranial nerve involvement in an HIV seronegative individual. Histology revealed infiltration of the cranial nerves by cryptococci causing axonal disruption with secondary demyelination in the absence of any evidence of inflammation or vasculitis. We believe that axonal damage underlies the pathogenesis of cranial nerve involvement in cryptococcal meningitis.
Subjects
free text keywords: Neurology. Diseases of the nervous system, RC346-429
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