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Publication . Article . 2015

The Study of Congenital Hypothyroidism Prevalence Using Screening in Azarshahr, East Azerbaijan Province, Iran, 2011

Ali Nayerpour; Sepide Shakeri-Gavgani; Azra Mamaghaniyan; Parinaz Rezadokht-Mamaghani; Soheila Shakeri-Gavgani; Jila Mahmoodi; Ali Jafari-Khounigh;
Open Access
Persian
Published: 01 Aug 2015 Journal: Taṣvīr-i salāmat, volume 3, issue 4, pages 24-29 (issn: 2008-9058, eissn: 2423-6640, Copyright policy )
Publisher: Tabriz University of Medical Sciences
Abstract

Background and objectives : Congenital hypothyroidism (CH) is one of the most prevalent causes of mental retardation which is preventable provided that earlier diagnosis and treatment are performed. The aim of this study was to investigate the prevalence of congenital hypothyroidism among newborns in Azarshahr during 2011. Material and Methods : This cross-sectional study was conducted on 1775 newborns in Azarshahr applying census method. In this regard, four drops of blood samples were taken preferably from each 3-5 day-old newborn’s heel using auto-lancet and then transferred to Whatman® 903 filter papers. Samples were checked to measure TSH level using ELISA method. Results : Program covering percentage was 95.9%. The disease prevalence was 1.12 per 1000 live births or one case per 887 live births. According to the results, 52.4% of the newborns were male. Samples in 84.6% of newborns were taken within 3rd-5th days of life and in 14.8%, within 6th-21st days of life. The TSH level in 97.5% of screened newborns was lower than 5 mu/L and in 1.6% of the samples was within the range of 5-9.9 mu/L. Recall rate was 1.7% and among them, two patients with hypothyroidism were found. The average age of treatment onset in patients was 20.5 days. Conclusion : Because of high prevalence of hypothyroidism in Azarshahr in comparison with other areas of Iran and the world, it is necessary to continue screening program.

Subjects by Vocabulary

Library of Congress Subject Headings: lcsh:Medicine (General) lcsh:R5-920

Subjects

Screening, Congenital Hypothyroidism, Thyroid, Prevalence, Azarshahr

17 references, page 1 of 2

1. Ooki S. Congenital hypothyroidism after assisted reproductive technology in Japan: comparison between multiples and singletons, 2005-2009. International Journal of Pediatric Endocrinology 2013; 2013: 5. [OpenAIRE]

2. after assisted reproductive technology in Japan: comparison between multiples and singletons, 2005-2009. International Journal of Pediatric Endocrinology 2013; 2013: 5.

7. Dorreh F, Chaijan PY, Javaheri J, Zeinalzadeh AH. Epidemiology of congenital hypothyroidism in Markazi province, Iran. J Clin Res Pediatr Endocrinol 2014; 6(2): 105-110. [OpenAIRE]

8. Cao XY, Jiang XM, Dou ZH, Rakeman MA, Zhang ML, O'Donnel K, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N Engl J Med 1994; 331: 1739-1744.

9. Klett M. Epidemiology of congenital hypothyroidism. Exp Clin Endocrinol Diabetes 1997; 4: 19-23.

10. Olney RS, Grosse SD, Vogt Jr RF. Prevalence of congenital hypothyroidism-Current trends and future directions: Workshop Summary. Pediatrics 2010; 125: 31-36.

11.Alm J, Larsson A, Zetterstorm R. Congenital Hypothyroidism in Sweden. Incidence and age at diagnosis. Acta Paediatr Scand 1978; 67(1): 1-3.

13. Mitchell ML, Hsu HW, Sahai I, Massachusetts Pediatric Endocrine Work Group. The increased incidence of congenital hypothyroidism: fact or fancy? Clin Endocrinol (Oxf) 2011; 75(6): 10-806.

14. Harris KB, Pass KA. Increase in congenital hypothyroidism in New York State and in the United States. Mol Genet Metab 2007, 91(3): 77-268.

17. Ordookhani A, Hedayati M, Mirmiran P, Hajipour R, Azizi F. High prevalence of neonatal hypothyroidism in Tehran. Iranian Journal of Endocrinology and Metabolism 2000; 2(4): 77-263.

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Article . 2013
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