publication . Article . 2010

Methylprednisolone and its related substances in freeze dried powders for injections

Ljiljana Solomun; Ivan Vuckovic; Svetlana Ibrić; Vlatka Vajs; Zorica Vujić;
Open Access English
  • Published: 01 Oct 2010 Journal: Journal of the Serbian Chemical Society (issn: 0352-5139, Copyright policy)
  • Publisher: Serbian Chemical Society
  • Country: Serbia
Abstract
In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections, was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylprednisolone esters (17-hydrogen succina...
Subjects
free text keywords: methylprednisolone sodium succinate, freeze-dried powder, container closure system, stability, impurities, Chemistry, QD1-999, General Chemistry, Chromatography, Hplc method, Nuclear magnetic resonance spectroscopy, Pharmaceutical Substances, Methylprednisolone, medicine.drug, medicine, Sodium succinate, Dosage form, Impurity
Funded by
EC| SGDBALTIC
Project
SGDBALTIC
The importance of submarine groundwater discharge for the southwestern Baltic Sea
  • Funder: European Commission (EC)
  • Project Code: 293499
  • Funding stream: FP7 | SP3 | PEOPLE
Communities
European Marine ScienceMarine Environmental Science: The importance of submarine groundwater discharge for the southwestern Baltic Sea
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