Common mutations identified in the MLH1 gene in familial Lynch syndrome

Article English OPEN
Jisha Elias; Coral Karunakaran; Snigdha Majumder; Malini Manoharan; Rakshit Shah; Yogesh Mistry; Rajesh Ramanuj; Niraj Bhatt; Arati Khanna- Gupta;
  • Publisher: Science Planet Inc.
  • Journal: Canadian Journal of Biotechnology (issn: 2560-8304)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.24870/cjb.2017-a238
  • Subject: Biotechnology | TP248.13-248.65
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | digestive system diseases | neoplasms | nutritional and metabolic diseases

Lynch syndrome (Hereditary Non Polyposis Colorectal Cancer, HNPCC) is one of the most common hereditary familial colorectal cancers (CRC) with an autosomal dominant pattern of inheritance. It accounts for 2-5% of the total CRCs reported worldwide. Although a lower incid... View more
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