publication . Article . 2017

Common mutations identified in the MLH1 gene in familial Lynch syndrome

Jisha Elias; Coral Karunakaran; Snigdha Majumder; Malini Manoharan; Rakshit Shah; Yogesh Mistry; Rajesh Ramanuj; Niraj Bhatt; Arati Khanna- Gupta;
Open Access English
  • Published: 01 Dec 2017 Journal: Canadian Journal of Biotechnology (issn: 2560-8304, Copyright policy)
  • Publisher: Science Planet Inc.
Abstract
Lynch syndrome (Hereditary Non Polyposis Colorectal Cancer, HNPCC) is one of the most common hereditary familial colorectal cancers (CRC) with an autosomal dominant pattern of inheritance. It accounts for 2-5% of the total CRCs reported worldwide. Although a lower incidence for CRCs have been observed in India, the last decade has shown a remarkable increase of CRC incidences (2-4 %). Features of Lynch syndrome associated colorectal cancer include early age of cancer onset, accelerated carcinogenesis of adenomas into carcinomas, and predilection to cancer of the proximal colon (about 70% of Lynch syndrome–related colorectal cancers occur in the right colon, w...
Subjects
mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalitiesdigestive system diseasesneoplasmsnutritional and metabolic diseases
free text keywords: Biotechnology, TP248.13-248.65
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