Imaging Herpes Simplex Virus Type 1 Amplicon Vector–Mediated Gene Expression in Human Glioma Spheroids

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Christine Kaestle ; Alexandra Winkeler ; Raphaela Richter ; Heinrich Sauer ; Jürgen Hescheler ; Cornel Fraefel ; Maria Wartenberg ; Andreas H. Jacobs (2011)
  • Publisher: SAGE Publishing
  • Journal: Molecular Imaging (issn: 1536-0121)
  • Related identifiers: doi: 10.2310/7290.2010.00036
  • Subject: Biology (General) | QH301-705.5
    mesheuropmc: embryonic structures

Vectors derived from herpes simplex virus type 1 (HSV-1) have great potential for transducing therapeutic genes into the central nervous system; however, inefficient distribution of vector particles in vivo may limit their therapeutic potential in patients with gliomas.... View more
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