publication . Article . 2019

The Association Between STAT4 rs7574865 Polymorphism and the Susceptibility of Autoimmune Thyroid Disease: A Meta-Analysis.

Xueren Gao; Jianguo Wang; Yongguo Yu;
Open Access English
  • Published: 07 Jan 2019 Journal: Frontiers in Genetics (issn: 1664-8021, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Objectives: The signal transducer and activator of transcription 4 (STAT4) gene encodes an important transcription factor that transmits signals induced by several cytokines associated with autoimmune diseases and has been identified as a susceptibility gene for numerous autoimmune disorders. The association between STAT4 rs7574865 polymorphism and the susceptibility of autoimmune thyroid disease (AITD) has been investigated in previous case-control studies. However, the investigation results were inconsistent. Hence, a meta-analysis was performed to draw a more reliable conclusion about it. Methods: All relevant studies were searched in Embase, PubMed, Web of S...
Subjects
free text keywords: STAT4, polymorphism, susceptibility, autoimmune thyroid disease, meta-analysis, Genetics, QH426-470, Original Research, Thyroiditis, medicine.disease, medicine, Disease, Biology, Population, education.field_of_study, education, Immunology, Subgroup analysis, Bioinformatics, Odds ratio, Polymorphism (computer science)
Related Organizations
28 references, page 1 of 2

Antonelli A.Ferrari S. M.Corrado A.Di Domenicantonio A.Fallahi P. (2015). Autoimmune thyroid disorders. Autoimmun. Rev. 14 174–180. 10.1016/j.autrev.2014.10.016 25461470 [OpenAIRE] [PubMed] [DOI]

Ban Y.Tozaki T.Taniyama M.Tomita M.Ban Y. (2005). Association of a CTLA-4 3′ untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity 38 151–153. 10.1080/08916930500050319 16040335 [OpenAIRE] [PubMed] [DOI]

Ben Hamad M.Cornelis F.Mbarek H.Chabchoub G.Marzouk S.Bahloul Z. (2011). Signal transducer and activator of transcription and the risk of rheumatoid arthritis and thyroid autoimmune disorders. Clin. Exp. Rheumatol. 29 269–274. 21418779 [OpenAIRE] [PubMed]

Brix T. H.Hegedüs L. (2012). Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. Clin. Endocrinol. 76 457–464. 10.1111/j.1365-2265.2011.04318.x 22168537 [OpenAIRE] [PubMed] [DOI]

Durães C.Moreira C. S.Alvelos I.Mendes A.Santos L. R.Machado J. C. (2014). Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease. PLoS One 9:e105492. 10.1371/journal.pone.0105492 25127106 [OpenAIRE] [PubMed] [DOI]

Fang M.Huang W.Mo D.Zhao W.Huang R. (2018). Association of five snps in cytotoxic T-lymphocyte antigen 4 and cancer susceptibility: evidence from 67 studies. Cell Physiol. Biochem. 47 414–427. 10.1159/000489953 29794444 [OpenAIRE] [PubMed] [DOI]

Gao X. R.Zhang S. L.Zhu Z. Z. (2015). Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer. Mol. Genet. Genomics 290 23–28. 10.1007/s00438-014-0896-3 25112403 [OpenAIRE] [PubMed] [DOI]

Gupta V.Kumar S.Pratap A.Singh R.Kumari R.Kumar S. (2018). Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus 27 1973–1979. 10.1177/0961203318786432 30041578 [OpenAIRE] [PubMed] [DOI]

Hiz M. M.KılıçS.Işık S.Ogretmen Z.Silan F. (2015). Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Cent. Eur. J. Immunol. 40 437–441. 10.5114/ceji.2015.57146 26862307 [OpenAIRE] [PubMed] [DOI]

Hollowell J. G.Staehling N. W.Flanders W. D.Hannon W. H.Gunter E. W.Spencer C. A. (2002). Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87 489–499. 10.1210/jcem.87.2.8182 11836274 [OpenAIRE] [PubMed] [DOI]

Jiang D. K.Sun J.Cao G.Liu Y.Lin D.Gao Y. Z. (2013). Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat. Genet. 45 72–75. 10.1038/ng.2483 23242368 [OpenAIRE] [PubMed] [DOI]

Kaplan M. H. (2005). STAT4: a critical regulator of inflammation in vivo. Immunol. Res. 31 231–242. 10.1385/IR:31:3:231 15888914 [OpenAIRE] [PubMed] [DOI]

Kawasaki A.Ito I.Hikami K.Ohashi J.Hayashi T.Goto D. (2008). Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res. Ther. 10:R113. 10.1186/ar2516 18803832 [OpenAIRE] [PubMed] [DOI]

Kobayashi S.Ikari K.Kaneko H.Kochi Y.Yamamoto K.Shimane K. (2008). Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum. 58 1940–1946. 10.1002/art.23494 18576330 [OpenAIRE] [PubMed] [DOI]

Korman B. D.Kastner D. L.Gregersen P. K.Remmers E. F. (2008). STAT4: genetics, mechanisms, and implications for autoimmunity. Curr. Allergy Asthma Rep. 8 398–403. 10.1007/s11882-008-0077-8 18682104 [OpenAIRE] [PubMed] [DOI]

28 references, page 1 of 2
Abstract
Objectives: The signal transducer and activator of transcription 4 (STAT4) gene encodes an important transcription factor that transmits signals induced by several cytokines associated with autoimmune diseases and has been identified as a susceptibility gene for numerous autoimmune disorders. The association between STAT4 rs7574865 polymorphism and the susceptibility of autoimmune thyroid disease (AITD) has been investigated in previous case-control studies. However, the investigation results were inconsistent. Hence, a meta-analysis was performed to draw a more reliable conclusion about it. Methods: All relevant studies were searched in Embase, PubMed, Web of S...
Subjects
free text keywords: STAT4, polymorphism, susceptibility, autoimmune thyroid disease, meta-analysis, Genetics, QH426-470, Original Research, Thyroiditis, medicine.disease, medicine, Disease, Biology, Population, education.field_of_study, education, Immunology, Subgroup analysis, Bioinformatics, Odds ratio, Polymorphism (computer science)
Related Organizations
28 references, page 1 of 2

Antonelli A.Ferrari S. M.Corrado A.Di Domenicantonio A.Fallahi P. (2015). Autoimmune thyroid disorders. Autoimmun. Rev. 14 174–180. 10.1016/j.autrev.2014.10.016 25461470 [OpenAIRE] [PubMed] [DOI]

Ban Y.Tozaki T.Taniyama M.Tomita M.Ban Y. (2005). Association of a CTLA-4 3′ untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity 38 151–153. 10.1080/08916930500050319 16040335 [OpenAIRE] [PubMed] [DOI]

Ben Hamad M.Cornelis F.Mbarek H.Chabchoub G.Marzouk S.Bahloul Z. (2011). Signal transducer and activator of transcription and the risk of rheumatoid arthritis and thyroid autoimmune disorders. Clin. Exp. Rheumatol. 29 269–274. 21418779 [OpenAIRE] [PubMed]

Brix T. H.Hegedüs L. (2012). Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. Clin. Endocrinol. 76 457–464. 10.1111/j.1365-2265.2011.04318.x 22168537 [OpenAIRE] [PubMed] [DOI]

Durães C.Moreira C. S.Alvelos I.Mendes A.Santos L. R.Machado J. C. (2014). Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease. PLoS One 9:e105492. 10.1371/journal.pone.0105492 25127106 [OpenAIRE] [PubMed] [DOI]

Fang M.Huang W.Mo D.Zhao W.Huang R. (2018). Association of five snps in cytotoxic T-lymphocyte antigen 4 and cancer susceptibility: evidence from 67 studies. Cell Physiol. Biochem. 47 414–427. 10.1159/000489953 29794444 [OpenAIRE] [PubMed] [DOI]

Gao X. R.Zhang S. L.Zhu Z. Z. (2015). Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer. Mol. Genet. Genomics 290 23–28. 10.1007/s00438-014-0896-3 25112403 [OpenAIRE] [PubMed] [DOI]

Gupta V.Kumar S.Pratap A.Singh R.Kumari R.Kumar S. (2018). Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus 27 1973–1979. 10.1177/0961203318786432 30041578 [OpenAIRE] [PubMed] [DOI]

Hiz M. M.KılıçS.Işık S.Ogretmen Z.Silan F. (2015). Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups. Cent. Eur. J. Immunol. 40 437–441. 10.5114/ceji.2015.57146 26862307 [OpenAIRE] [PubMed] [DOI]

Hollowell J. G.Staehling N. W.Flanders W. D.Hannon W. H.Gunter E. W.Spencer C. A. (2002). Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87 489–499. 10.1210/jcem.87.2.8182 11836274 [OpenAIRE] [PubMed] [DOI]

Jiang D. K.Sun J.Cao G.Liu Y.Lin D.Gao Y. Z. (2013). Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat. Genet. 45 72–75. 10.1038/ng.2483 23242368 [OpenAIRE] [PubMed] [DOI]

Kaplan M. H. (2005). STAT4: a critical regulator of inflammation in vivo. Immunol. Res. 31 231–242. 10.1385/IR:31:3:231 15888914 [OpenAIRE] [PubMed] [DOI]

Kawasaki A.Ito I.Hikami K.Ohashi J.Hayashi T.Goto D. (2008). Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res. Ther. 10:R113. 10.1186/ar2516 18803832 [OpenAIRE] [PubMed] [DOI]

Kobayashi S.Ikari K.Kaneko H.Kochi Y.Yamamoto K.Shimane K. (2008). Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum. 58 1940–1946. 10.1002/art.23494 18576330 [OpenAIRE] [PubMed] [DOI]

Korman B. D.Kastner D. L.Gregersen P. K.Remmers E. F. (2008). STAT4: genetics, mechanisms, and implications for autoimmunity. Curr. Allergy Asthma Rep. 8 398–403. 10.1007/s11882-008-0077-8 18682104 [OpenAIRE] [PubMed] [DOI]

28 references, page 1 of 2
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publication . Article . 2019

The Association Between STAT4 rs7574865 Polymorphism and the Susceptibility of Autoimmune Thyroid Disease: A Meta-Analysis.

Xueren Gao; Jianguo Wang; Yongguo Yu;