Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

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Su, Jung-Chen; Chang, Chuan-Hsun; Wu, Szu-Hsien; Shiau, Chung-Wai;

Abstract The unregulated activation of STAT3 has been demonstrated to occur in many cancers and enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors, and hormones triggers this activation by phosphorylating STAT3 at tyrosine 705. Nov... View more
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