publication . Article . 2018

Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Compounds Containing Carboxyl Groups Using CdTe and CuO Nanoparticles

Taro Sato; Megumi Sakurai; Jiawei Xu; Soichi Sato; Tatsuya Fujino;
Open Access
  • Published: 01 Mar 2018 Journal: Applied Sciences, volume 8, page 492 (eissn: 2076-3417, Copyright policy)
  • Publisher: MDPI AG
Abstract
Matrix-assisted laser desorption ionization mass spectrometry of compounds containing carboxyl groups was carried out by using semiconductor nanoparticles (CdTe and CuO) as the matrix. Salicylic acid (Sal), glucuronic acid (Glu), ibuprofen (Ibu), and tyrosine (Tyr) were ionized as deprotonated species (carboxylate anions) by using electrons ejected from CdTe after the photoexcitation. When CuO was used as the matrix, the peak intensity of Tyr became high compared with that obtained with CdTe. Measurements of model peptides, angiotensin II (AngII) and substance P (SubP), were also carried out but the obtained peak intensities were very low. In order to explain th...
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doi: 10.3390/app8040492
Subjects
free text keywords: MALDI, semiconductor, nanoparticles, carboxyl group, Technology, T, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, QD1-999, Matrix-assisted laser desorption/ionization, Chemistry, Inorganic chemistry, Carboxylate, chemistry.chemical_compound, Deprotonation, Angiotensin II, Desorption, Ionization, Mass spectrometry, Nanoparticle
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