Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways

Article English OPEN
Feixia Gao; Chun Zhou; Weiyu Qiu; Haiwang Wu; Jing Li; Jinting Peng; Min Qiu; Chun Liang; Jie Gao; Songping Luo;
(2018)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports (issn: 2045-2322)
  • Related identifiers: doi: 10.1038/s41598-018-35732-6
  • Subject: Medicine | R | Science | Q

Abstract Miscarriage is a common condition during pregnancy and its mechanisms remain largely unknown. Extravillous trophoblast (EVT) cell invasion is required to maintain normal pregnancy and its malfunction has been proposed as a major cause for miscarriage. Homeostas... View more
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