Local application of a gentamicin-loaded thermo-responsive hydrogel allows for fracture healing upon clearance of a high Staphylococcus aureus load in a rabbit model

Article English OPEN
G-JA ter Boo; T Schmid; I Zderic; D Nehrbass; K Camenisch; RG Richards; DW Grijpma; TF Moriarty; D Eglin;
(2018)
  • Publisher: AO Research Institute Davos
  • Journal: European Cells & Materials (issn: 1473-2262, eissn: 1473-2262)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.22203/eCM.v035a11
  • Subject: Biomedical Engineering | Prophylaxis | Fracture healing | Bioengineering | Cell Biology | Thermo-responsive hydrogel | Biochemistry | RD1-811 | Diseases of the musculoskeletal system | RC925-935 | Biomaterials | Biomaterial-associated infection | Staphylococcus aureus | Surgery

ntibiotic-loaded biomaterials (ALBs) have emerged as a potential useful adjunctive antimicrobial measure for the prevention of infection in open fracture care. A biodegradable thermo-responsive poly(N-isopropylacrylamide) grafted hyaluronic acid (HApN) hydrogel loaded w... View more
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