publication . Article . 2018

Local application of a gentamicin-loaded thermo-responsive hydrogel allows for fracture healing upon clearance of a high Staphylococcus aureus load in a rabbit model

G-JA ter Boo; T Schmid; I Zderic; D Nehrbass; K Camenisch; RG Richards; DW Grijpma; TF Moriarty; D Eglin;
Open Access English
  • Published: 01 Mar 2018
  • Country: Netherlands
Abstract
ntibiotic-loaded biomaterials (ALBs) have emerged as a potential useful adjunctive antimicrobial measure for the prevention of infection in open fracture care. A biodegradable thermo-responsive poly(N-isopropylacrylamide) grafted hyaluronic acid (HApN) hydrogel loaded with gentamicin has recently been shown to prevent implant-related infection in a rabbit osteosynthesis model. The primary aim of this study was to determine the influence of this HApN hydrogel on bone healing at an early stage (4 weeks). A rabbit humeral osteotomy model with plating osteosynthesis was used to compare fracture healing in rabbits receiving the hydrogel as compared with control anima...
Subjects
free text keywords: Biomaterial-associated infection, Fracture healing, Prophylaxis, Staphylococcus aureus, Thermo-responsive hydrogel, Bioengineering, Biochemistry, Biomaterials, Biomedical Engineering, Cell Biology, Surgery, RD1-811, Diseases of the musculoskeletal system, RC925-935
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