publication . Article . Other literature type . 2018

Lignans From Forsythia x Intermedia Leaves and Flowers Attenuate the Pro-inflammatory Function of Leukocytes and Their Interaction With Endothelial Cells.

Michalak, Barbara; Filipek, Agnieszka; Chomicki, Piotr; Pyza, Małgorzata; Woźniak, Marta; Żyżyńska-Granica, Barbara; Piwowarski, Jakub P.; Kicel, Agnieszka; Olszewska, Monika A.; Kiss, Anna K.;
Open Access
  • Published: 01 Apr 2018 Journal: Frontiers in Pharmacology, volume 9 (eissn: 1663-9812, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Aim of the study: Taking into account that overactivated leukocytes are an important factor in the development of many chronic diseases, we investigated the activity of phytochemically characterized (HPLC-DAD-MSn) extracts from forsythia leaves and flowers on the pro- and anti-inflammatory functions of leukocytes (effects on IL-1β, IL-8, TNF-α, and TGFβ release) and their adherence to endothelial cells. Using bio-guided fractionation, we isolated the active compounds and determined their biological activity, and we included the positive control quercetin. Methods: The effect on IL-1β, TNF-α, IL-8, and TGF-α production by leukocytes was measured by enzyme-linked ...
Subjects
free text keywords: Pharmacology (medical), Pharmacology, Cell adhesion molecule, p38 mitogen-activated protein kinases, Biological activity, Monocyte, medicine.anatomical_structure, medicine, Enterolactone, chemistry.chemical_compound, chemistry, Forsythia, biology.organism_classification, biology, business.industry, business, Arctigenin, Flow cytometry, medicine.diagnostic_test, Forsythia x intermedia, Oleaceae, lignans, pro-inflammatory mediators, neutrophils, Therapeutics. Pharmacology, RM1-950, Original Research, macrophages, endothelial cells
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