Hormonal modulation of breast cancer gene expression: implications for intrinsic subtyping in pre-menopausal women

Article English OPEN
Sarah M Bernhardt; Pallave Dasari; David Walsh; Amanda R Townsend; Amanda R Townsend; Timothy J Price; Timothy J Price; Wendy V Ingman;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Oncology (issn: 2234-943X)
  • Related identifiers: doi: 10.3389/fonc.2016.00241/full, doi: 10.3389/fonc.2016.00241
  • Subject: Gene Expression | Hormones | Menstrual Cycle | Intrinsic subtyping | pre-menopausal breast cancer | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | RC254-282

Clinics are increasingly adopting gene expression profiling to diagnose breast cancer subtype, providing an intrinsic, molecular portrait of the tumour. For example, the PAM50-based Prosigna test quantifies expression of 50 key genes to classify breast cancer subtype, a... View more
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