publication . Article . 2016

Hormonal modulation of breast cancer gene expression: implications for intrinsic subtyping in pre-menopausal women

Sarah M Bernhardt; Pallave Dasari; David Walsh; Amanda R Townsend; Amanda R Townsend; Timothy J Price; Timothy J Price; Wendy V Ingman;
Open Access English
  • Published: 14 Nov 2016 Journal: Frontiers in Oncology, volume 6
  • Publisher: Frontiers Media S.A.
Abstract
Clinics are increasingly adopting gene expression profiling to diagnose breast cancer subtype, providing an intrinsic, molecular portrait of the tumour. For example, the PAM50-based Prosigna test quantifies expression of 50 key genes to classify breast cancer subtype, and this method of classification has been demonstrated to be superior over traditional immunohistochemical methods that detect proteins, to predict risk of disease recurrence. However, these tests were largely developed and validated using breast cancer samples from post-menopausal women. Thus, the accuracy of such tests has not been explored in the context of the hormonal fluctuations in estrogen...
Persistent Identifiers
Subjects
free text keywords: Gene Expression, Hormones, Menstrual Cycle, Intrinsic subtyping, pre-menopausal breast cancer, Oncology, premenopausal breast cancer, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Estrogen, medicine.drug_class, medicine, media_common.quotation_subject, media_common, Disease, Subtyping, Gynecology, medicine.medical_specialty, business.industry, business, Internal medicine, Breast cancer, medicine.disease, Immunohistochemistry, Hormone, Concordance
Related Organizations
146 references, page 1 of 10

1 AIHW. Breast Cancer in Australia: An Overview. Canberra: AIHW (2012).

2 AIHW. Cancer in Australia: An Overview 2014. Canberra: AIHW (2014).

3 Brennan M French J Houssami N Kirk J Boyages J. Breast cancer in young women. Aust Fam Physician (2005) 34(10):851–5.16217572 [PubMed]

4 Fata JE Chaudhary V Khokha R. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle. Biol Reprod (2001) 65(3):680–8.10.1095/biolreprod65.3.680 11514328 [OpenAIRE] [PubMed] [DOI]

5 Ramakrishnan R Khan SA Badve S. Morphological changes in breast tissue with menstrual cycle. Mod Pathol (2002) 15(12):1348–56.10.1097/01.MP.0000039566.20817.46 12481017 [OpenAIRE] [PubMed] [DOI]

6 Chavez-MacGregor M van Gils CH van der Schouw YT Monninkhof E van Noord PA Peeters PH. Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women. Breast Cancer Res Treat (2008) 108(1):101–12.10.1007/s10549-007-9574-z 18274909 [OpenAIRE] [PubMed] [DOI]

7 Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol (2012) 13(11):1141–51.10.1016/S1470-2045(12)70425-4 23084519 [OpenAIRE] [PubMed] [DOI]

8 Cheang MC Voduc KD Tu D Jiang S Leung S Chia SK Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial. Clin Cancer Res (2012) 18(8):2402–12.10.1158/1078-0432.CCR-11-2956 22351696 [OpenAIRE] [PubMed] [DOI]

9 Chia SK Bramwell VH Tu D Shepherd LE Jiang S Vickery T A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen. Clin Cancer Res (2012) 18(16):4465–72.10.1158/1078-0432.CCR-12-0286 22711706 [OpenAIRE] [PubMed] [DOI]

10 Andres AC Strange R. Apoptosis in the estrous and menstrual cycles. J Mammary Gland Biol Neoplasia (1999) 4(2):221–8.10.1023/A:1018737510695 10426401 [PubMed] [DOI]

11 Need EF Atashgaran V Ingman WV Dasari P. Hormonal regulation of the immune microenvironment in the mammary gland. J Mammary Gland Biol Neoplasia (2014) 19(2):229–39.10.1007/s10911-014-9324-x 24993978 [OpenAIRE] [PubMed] [DOI]

12 Ferguson JE Schor AM Howell A Ferguson MW. Changes in the extracellular matrix of the normal human breast during the menstrual cycle. Cell Tissue Res (1992) 268(1):167–77.10.1007/BF00338066 1499048 [OpenAIRE] [PubMed] [DOI]

13 Navarrete MA Maier CM Falzoni R Quadros LG Lima GR Baracat EC Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle. Breast Cancer Res (2005) 7(3):R306–13.10.1186/bcr994 15987425 [OpenAIRE] [PubMed] [DOI]

14 Vogel PM Georgiade NG Fetter BF Vogel FS McCarty KS Jr. The correlation of histologic changes in the human breast with the menstrual cycle. Am J Pathol (1981) 104(1):23–34.7258295 [OpenAIRE] [PubMed]

15 Giovannelli P Di Donato M Giraldi T Migliaccio A Castoria G Auricchio F. Targeting rapid action of sex-steroid receptors in breast and prostate cancers. Front Biosci (Elite Ed) (2012) 4:453–61.10.2741/e390 22201885 [OpenAIRE] [PubMed] [DOI]

146 references, page 1 of 10
Abstract
Clinics are increasingly adopting gene expression profiling to diagnose breast cancer subtype, providing an intrinsic, molecular portrait of the tumour. For example, the PAM50-based Prosigna test quantifies expression of 50 key genes to classify breast cancer subtype, and this method of classification has been demonstrated to be superior over traditional immunohistochemical methods that detect proteins, to predict risk of disease recurrence. However, these tests were largely developed and validated using breast cancer samples from post-menopausal women. Thus, the accuracy of such tests has not been explored in the context of the hormonal fluctuations in estrogen...
Persistent Identifiers
Subjects
free text keywords: Gene Expression, Hormones, Menstrual Cycle, Intrinsic subtyping, pre-menopausal breast cancer, Oncology, premenopausal breast cancer, Review, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Estrogen, medicine.drug_class, medicine, media_common.quotation_subject, media_common, Disease, Subtyping, Gynecology, medicine.medical_specialty, business.industry, business, Internal medicine, Breast cancer, medicine.disease, Immunohistochemistry, Hormone, Concordance
Related Organizations
146 references, page 1 of 10

1 AIHW. Breast Cancer in Australia: An Overview. Canberra: AIHW (2012).

2 AIHW. Cancer in Australia: An Overview 2014. Canberra: AIHW (2014).

3 Brennan M French J Houssami N Kirk J Boyages J. Breast cancer in young women. Aust Fam Physician (2005) 34(10):851–5.16217572 [PubMed]

4 Fata JE Chaudhary V Khokha R. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle. Biol Reprod (2001) 65(3):680–8.10.1095/biolreprod65.3.680 11514328 [OpenAIRE] [PubMed] [DOI]

5 Ramakrishnan R Khan SA Badve S. Morphological changes in breast tissue with menstrual cycle. Mod Pathol (2002) 15(12):1348–56.10.1097/01.MP.0000039566.20817.46 12481017 [OpenAIRE] [PubMed] [DOI]

6 Chavez-MacGregor M van Gils CH van der Schouw YT Monninkhof E van Noord PA Peeters PH. Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women. Breast Cancer Res Treat (2008) 108(1):101–12.10.1007/s10549-007-9574-z 18274909 [OpenAIRE] [PubMed] [DOI]

7 Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol (2012) 13(11):1141–51.10.1016/S1470-2045(12)70425-4 23084519 [OpenAIRE] [PubMed] [DOI]

8 Cheang MC Voduc KD Tu D Jiang S Leung S Chia SK Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial. Clin Cancer Res (2012) 18(8):2402–12.10.1158/1078-0432.CCR-11-2956 22351696 [OpenAIRE] [PubMed] [DOI]

9 Chia SK Bramwell VH Tu D Shepherd LE Jiang S Vickery T A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen. Clin Cancer Res (2012) 18(16):4465–72.10.1158/1078-0432.CCR-12-0286 22711706 [OpenAIRE] [PubMed] [DOI]

10 Andres AC Strange R. Apoptosis in the estrous and menstrual cycles. J Mammary Gland Biol Neoplasia (1999) 4(2):221–8.10.1023/A:1018737510695 10426401 [PubMed] [DOI]

11 Need EF Atashgaran V Ingman WV Dasari P. Hormonal regulation of the immune microenvironment in the mammary gland. J Mammary Gland Biol Neoplasia (2014) 19(2):229–39.10.1007/s10911-014-9324-x 24993978 [OpenAIRE] [PubMed] [DOI]

12 Ferguson JE Schor AM Howell A Ferguson MW. Changes in the extracellular matrix of the normal human breast during the menstrual cycle. Cell Tissue Res (1992) 268(1):167–77.10.1007/BF00338066 1499048 [OpenAIRE] [PubMed] [DOI]

13 Navarrete MA Maier CM Falzoni R Quadros LG Lima GR Baracat EC Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle. Breast Cancer Res (2005) 7(3):R306–13.10.1186/bcr994 15987425 [OpenAIRE] [PubMed] [DOI]

14 Vogel PM Georgiade NG Fetter BF Vogel FS McCarty KS Jr. The correlation of histologic changes in the human breast with the menstrual cycle. Am J Pathol (1981) 104(1):23–34.7258295 [OpenAIRE] [PubMed]

15 Giovannelli P Di Donato M Giraldi T Migliaccio A Castoria G Auricchio F. Targeting rapid action of sex-steroid receptors in breast and prostate cancers. Front Biosci (Elite Ed) (2012) 4:453–61.10.2741/e390 22201885 [OpenAIRE] [PubMed] [DOI]

146 references, page 1 of 10
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