publication . Article . 2014

Comparative Aspects of Human, Canine, and Feline Obesity and Factors Predicting Progression to Diabetes

Margarethe Hoenig;
Open Access English
  • Published: 01 Aug 2014 Journal: Veterinary Sciences (issn: 2306-7381, Copyright policy)
  • Publisher: MDPI AG
Abstract
Obesity and diabetes mellitus are common diseases in humans, dogs and cats and their prevalence is increasing. Obesity has been clearly identified as a risk factor for type 2 diabetes in humans and cats but recent data are missing in dogs, although there is evidence that the unprecedented rise in canine obesity in the last decade has led to a rise in canine diabetes of similar magnitude. The insulin resistance of obesity has often been portrayed as major culprit in the loss of glucose control; however, insulin resistance alone is not a good indicator of progression to diabetes in people or pets. A loss of beta cell function is necessary to provide the link to im...
Subjects
free text keywords: diabetes, obesity, beta cells, gluconeogenesis, glycolysis, cytokines, adiponectin, leptin, insulin, fructosamine, Veterinary medicine, SF600-1100, chemistry.chemical_compound, chemistry, Internal medicine, medicine.medical_specialty, medicine, Immunology, medicine.disease, medicine.medical_treatment, Type 2 diabetes, Insulin resistance, business.industry, business, Diabetes mellitus, Endocrinology
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