Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Article English OPEN
Ji-Hun An ; Changjin Lim ; Hyung Chul Ryu ; Jae Sun Kim ; Hyuk Min Kim ; Alice Nguvoko Kiyonga ; Minho Park ; Young-Ger Suh ; Gyu Hwan Park ; Kiwon Jung (2017)
  • Publisher: MDPI AG
  • Journal: Crystals (issn: 2073-4352)
  • Related identifiers: doi: 10.3390/cryst7120365
  • Subject: Febuxostat | cocrystal | solid-state NMR | solubility | active pharmaceutical ingredient | Crystallography | QD901-999

Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation. In order to achieve a goal of improv... View more
Share - Bookmark