publication . Article . Other literature type . 2015

Memory T Cell Migration

Qianqian Zhang; Fadi G. Lakkis;
Open Access
  • Published: 02 Oct 2015 Journal: Frontiers in Immunology, volume 6 (eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media SA
Abstract
Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy. Therefore, a more thorough understanding of memory T cell biology is needed to improve the survival of transplanted organs without compromising the host’s ability to fight infections. This review will focus on the mechanisms by which memory T cells migrate to the site where their target antigen is present, with particular emphasis on their migration to transplanted orga...
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Persistent Identifiers

doi: 10.3389/fimmu.2015.00504

pmc: PMC4591505

pmid: 26483794

Subjects
free text keywords: Review, memory T cell subsets, lymphocyte migration, graft rejection, Subsets, Circulation patterns, peripheral migration, Transplantation relevance, Biology, Organ transplantation, medicine.medical_specialty, medicine, Memory T cell, medicine.anatomical_structure, Acquired immune system, Effector, Transplanted Organs, Immunology, Immunological memory, Transplantation, Organism, lcsh:Immunologic diseases. Allergy, lcsh:RC581-607
Related Organizations
Funded by
NIH| T Cell Memory in Organ Transplantation
Project
T Cell Memory in Organ Transplantation
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI049466-08
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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