publication . Article . 2018

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Liuming Qiu; Pei Wang; Ge Liao; Yanbo Zeng; Caihong Cai; Fandong Kong; Zhikai Guo; Peter Proksch; Haofu Dai; Wenli Mei;
Open Access English
  • Published: 01 Mar 2018 Journal: Marine Drugs (issn: 1660-3397, Copyright policy)
  • Publisher: MDPI AG
Abstract
Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.
Subjects
free text keywords: endophytic fungus, Penicillium sp., sesquiterpenoids, cytotoxicity, Biology (General), QH301-705.5, Article, Drug Discovery, Mangrove, Penicillium, biology.organism_classification, biology, Fermentation broth, Penicillium sp. J, Botany, Bioassay
Related Organizations

Gunatilaka, A.A.L. Natural products from plant-associatedmicroorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence. J. Nat. Prod. 2006, 69, 509-526. [CrossRef] [PubMed] Guo, B.; Wang, Y.; Sun, X.; Tang, K. Bioactive natural products from endophytes: A review. [OpenAIRE]

Appl. Biochem. Microbiol. 2008, 44, 136-142. [CrossRef] Aly, A.H.; Debbab, A.; Proksch, P. Fungal endophytes: Unique plant inhabitants with great promises.

Appl. Microbiol. Biotechnol. 2011, 90, 1829-1845. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2012, 29, 144-222. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2013, 30, 237-323. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2014, 31, 160-258. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2015, 32, 116-211. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2016, 33, 382-431. [CrossRef] [PubMed] Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munroa, M.H.G.; Prinsepd, M.R. Marine natural products.

Nat. Prod. Rep. 2017, 34, 235-294. [CrossRef] [PubMed] 10. Li, H.X.; Jiang, J.Y.; Liu, Z.M.; Lin, S.; Xia, G.P.; Xia, X.K.; Dingm, B.; He, L.; Lu, Y.J.; She, Z.G.

12. Kong, F.D.; Wang, Y.; Liu, P.P.; Tian, H.D.; Zhu, W.M. Thiodiketopiperazines from the marine-derived Fungus Phoma sp. OUCMDZ-1847. J. Nat. Prod. 2014, 77, 132-137. [CrossRef] [PubMed] 13. Jin, P.F.; Zuo, W.J.; Guo, Z.K.; Mei, W.L.; Dai, H.F. Metabolites from the endophytic fungus Penicillium sp.

FJ-1 of Ceriops tagal. Acta Pharm. Sin. 2013, 48, 1688-1691.

Batal. Tetrahedron 2013, 69, 6574-6578. [CrossRef] 14. Liu, M.L.; Duan, Y.H.; Zhang, J.B.; Yu, Y.; Dai, Y.; Yao, X.S. Novel sesquiterpenes from Nardostachys chinensis 15. Di, B.L.; Pescitelli, G.; Pratelli, C.; Pini, D.; Salvadori, P. Determination of absolute configuration of acyclic 1,2-diols with Mo2(OAc)4.1.Snatzke's method revisited. J. Org. Chem. 2001, 66, 4819-4825.

16. Gorecki, M.; Jablonska, E.; Kruszewska, A.; Suszczynska, A.; Urbanczyk-Lipkowska, Z.; Gerards, M.; Morzycki, J.W.; Szczepek, W.J.; Frelek, J. Practical method for the absolute configuration assignment of tert/tert 1,2-diols using their complexes with Mo2(OAc)4. J. Org. Chem. 2007, 72, 2906-2916. [CrossRef] 17. [OpenAIRE]

18. Fu, P.; Kong, F.D.; Wang, Y.F.; Wang, Y.; Liu, P.P.; Zuo, G.Y.; Zhu, W.M. Antibiotic metabolites from the coral-associated actinomycete Streptomyces sp. OUCMDZ-1703. Chin. J. Chem. 2013, 31, 100-104. [CrossRef] 19. Chen, S.X.; Ren, F.X.; Niu, S.B.; Liu, X.Z.; Che, Y.S. Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum. J. Nat. Prod. 2014, 77, 9-14. [CrossRef] [PubMed]

Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2018

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Liuming Qiu; Pei Wang; Ge Liao; Yanbo Zeng; Caihong Cai; Fandong Kong; Zhikai Guo; Peter Proksch; Haofu Dai; Wenli Mei;