publication . Article . 2011

The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus

Arakelova Elina Alexandrovna; Mamikonyan Ashot Andreevich; Мамиконян Ашот Андреевич; Геворкян Астхик Артавазовна; Gevorkyan Astkhik Artavazdovna; Boyadzhyan Anna Surenovna; Arakelyan Arsen Artashesovich; Овсепян Мери Робертовна; Бояджян Анна Суреновна; Аракелова Элина Александровна; ...
Open Access English
  • Published: 01 Sep 2011 Journal: Saharnyj Diabet (issn: 2072-0351, eissn: 2072-0378, Copyright policy)
  • Publisher: UP Print
Abstract
<jats:p>Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects. Materials and methods. 37 DM2 patients (7 men, 26 women, mean age 58?9 years (M?б) and 37 healthy subjects without a family history of hereditarydiabetes (17 men, 20 women, mean age 52?12 years). Serum MAC levels were measured by ELISA, C1 and C3 hemolytic activities by usingrabbit antibody-sensitized ram erythrocytes and C1, C3-deficient sera. Results. Mean values of all measured parameters in DM2 patie...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: type 2 diabetes mellitus, membrane attack complex, complement system, Nutritional diseases. Deficiency diseases, RC620-627, Internal Medicine, Endocrinology, Diabetes and Metabolism, Endocrinology, Diabetes mellitus, medicine.disease, medicine, Pathogenesis, Hyperactivation, Complement membrane attack complex, medicine.medical_specialty, Cytotoxic T cell, business.industry, business, Immunology, Family history
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