publication . Article . 2015

Ovariectomy-induced chronic abdominal hypernociception in rats: Relation with brain oxidative stress

Bárbara B. Garrido-Suárez; Gabino Garrido-Garrido; Marian Castro Labrada; Addis Bellma Menéndez; Roberto Menéndez Soto del Valle; René Delgado-Hernández;
Open Access English
  • Published: 01 Dec 2015 Journal: Journal of Pharmacy & Pharmacognosy Research (issn: 0719-4250, Copyright policy)
  • Publisher: Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA)
Context: Ovarian hormone deficiency observed in menopausal women increases the production of reactive oxygen species, which could be implicated in central sensitization subjacent in chronic functional pain syndromes. Aims: To examine the hyperalgesic state induced by ovariectomy in adult rats and its relation to some oxidative stress outcomes. Methods: The female Wistar rats were divided into normal, sham ovariectomized (OVX) and OVX groups, which were tested for mechanical and thermal hypernociception during 6 weeks and a single acetic acid-induced test 6 weeks after surgery. Redox biomarkers determinations of superoxide dismutase (SOD) enzyme activity, glutath...
free text keywords: Functional pain syndromes, hyperalgesia, hypernociception, ovariectomized rats, ovariectomy, pain, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441
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