publication . Article . 2006

Artemisia vulgaris pollen allergoids digestibility in the simulated conditions of the gastrointestinal tract

RATKO M. JANKOV; NATALIJA DJ. POLOVIC; MARIJA DJ. GAVROVIC-JANKULOVIC; LIDIJA BURAZER; DANICA DJERGOVIC-PETROVIC; OLGA VUCKOVIC; OLIKA DROBNJAK; ZORICA SPORCIC; MARINA ATANASKOVIC-MARKOVIC; RATKO M. JANKOV;
Open Access
  • Published: 01 Sep 2006 Journal: Journal of the Serbian Chemical Society, volume 71, pages 879-888 (issn: 0352-5139, Copyright policy)
  • Publisher: National Library of Serbia
  • Country: Serbia
Abstract
Chemically modified allergens (allergoids) have found use in both traditional and novel forms of immunotherapy of allergic disorders. Novel forms of immunotherapy include local allergen delivery, via the gastrointestinal tract. This study conveys the gastrointestinal stability of three types of mugwort pollen allergoids under simulated conditions of the gut. Allergoids of the pollen extract of Artemisia vulgaris were obtained by means of potassium cyanate, succinic and maleic anhydride. Gastrointestinal tract conditions (saliva, and gastric fluid) were simulated in accordance with the EU Pharmacopoeia. The biochemical and immunochemical properties of the derivat...
Subjects
free text keywords: mugwort pollen, chemical modification, maleic anhydride, potassium cyanate, succinic anhydride, General Chemistry, Mugwort, Biochemistry, Artemisia vulgaris, biology.organism_classification, biology, Chemistry, Digestion, Allergoid, Saliva, Allergen, medicine.disease_cause, medicine, Immunoglobulin E, biology.protein, Gastrointestinal tract, QD1-999

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publication . Article . 2006

Artemisia vulgaris pollen allergoids digestibility in the simulated conditions of the gastrointestinal tract

RATKO M. JANKOV; NATALIJA DJ. POLOVIC; MARIJA DJ. GAVROVIC-JANKULOVIC; LIDIJA BURAZER; DANICA DJERGOVIC-PETROVIC; OLGA VUCKOVIC; OLIKA DROBNJAK; ZORICA SPORCIC; MARINA ATANASKOVIC-MARKOVIC; RATKO M. JANKOV;