publication . Article . 2016

MODERN PHARMACOTHERAPY OF THE STABLE ANGINA: POSSIBILITIES AND PROSPECTS OF NICORANDIL IMPLEMENTATION

Z. M. Sizova; E. V. Shikh; V. L. Zakharova; E. V. Smirnova;
Open Access English
  • Published: 01 Jan 2016 Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii (issn: 1819-6446, eissn: 2225-3653, Copyright policy)
  • Publisher: Stolichnaya Izdatelskaya Kompaniya
Abstract
Aim. To evaluate antianginal efficacy and safety of nicorandil for angina attack prevention and relief in patients with ischemic heart disease (IHD) and symptoms of stable angina class 2-3.Material and methods. 30 patients with stable angina class 2-3 (17 men, 13 women; aged 58.6±5.8 y.o.) were included into the study. All patients received amlodipine 10 mg QD within 2 weeks. For angina attack relief patients used nicorandil 10-20 mg and in case of its inefficacy — nitroglycerin. In 2 weeks all patients were randomized in 2 groups. Patients of the 1st group (n=15) received nicorandil 20 mg TID, patients of the 2nd group (n=15) — amlodipine 10 mg QD. The study du...
Subjects
mesheuropmc: cardiovascular system
free text keywords: RC666-701, RM1-950, nicorandil, Therapeutics. Pharmacology, stable angina, Diseases of the circulatory (Cardiovascular) system, ischemic heart disease, antianginal therapy
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