Inhibition of Cartilage Acidic Protein 1 Reduces Ultraviolet B Irradiation Induced-Apoptosis through P38 Mitogen-Activated Protein Kinase and Jun Amino-Terminal Kinase Pathways

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Yinghong Ji; Xianfang Rong; Dan Li; Lei Cai; Jun Rao; Yi Lu;
(2016)
  • Publisher: Cell Physiol Biochem Press GmbH & Co KG
  • Journal: Cellular Physiology and Biochemistry (issn: 1015-8987, eissn: 1421-9778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1159/000447920
  • Subject: Cataract | UVB irradiation induced-apoptosis | CRTAC1 | p38 | JNK1/2 | Physiology | QP1-981 | Biochemistry | QD415-436

Background/Aims: Ultraviolet B (UVB) irradiation can easily induce apoptosis in human lens epithelial cells (HLECs) and further lead to various eye diseases including cataract. Here for the first time, we investigated the role of cartilage acidic protein 1 (CRTAC1) gene... View more
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