publication . Article . 2013

RP-HPLC assay method development for Paracetamol and Lornoxicam in combination and characterization of oxidative degradation products of Lornoxicam

Jain Pritam S.; Patel Miketa A.; Chaudhari Amar J.; Surana Sanjay J.;
Open Access
  • Published: 01 Jan 2013 Journal: Chemical Industry and Chemical Engineering Quarterly, volume 19, pages 471-484 (issn: 1451-9372, eissn: 2217-7434, Copyright policy)
  • Publisher: National Library of Serbia
Abstract
A simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous determination of Paracetamol and Lornoxicam from tablets and to characterize degradation products of Lornoxicam by reverse phase C18 column (Inertsil ODS 3V C-18, 250 x 4.6 mm, 5 μ). The sample was analyzed using Buffer (0.02504 Molar): Methanol in the ratio of 45:55, as a mobile phase at a flow rate of 1.5 mL/min and detection at 290 nm. The retention time for Paracetamol and Lornoxicam was found to be 2.45 and 9.40 min respectively. The method can be used for estimation of combination of these drugs in tablets. The method w...
Subjects
free text keywords: General Chemical Engineering, RP-HPLC, lornoxicam, validation, stability indicating, force degradation study, tablet formulation, Chemical engineering, TP155-156, Chemical industries, HD9650-9663
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