publication . Other literature type . Article . 2018

Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution

David A. Kennedy; Patricia A. Dunn; Andrew F. Read;
Open Access
  • Published: 01 Jun 2018
  • Publisher: Elsevier BV
Marek's disease virus (MDV) is a pathogen of chickens whose control has twice been undermined by pathogen evolution. Disease ecology is believed to be the main driver of this evolution, yet mathematical models of MDV disease ecology have never been confronted with data to test their reliability. Here, we develop a suite of MDV models that differ in the ecological mechanisms they include. We fit these models with maximum likelihood using iterated filtering in ‘pomp’ to data on MDV concentration in dust collected from two commercial broiler farms. We find that virus dynamics are influenced by between-flock variation in host susceptibility to virus, shedding rate f...
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Medical Subject Headings: animal diseasesvirusesanimal structures
free text keywords: Article, Public Health, Environmental and Occupational Health, Epidemiology, Microbiology, Parasitology, Virology, Infectious Diseases, Disease ecology, Marek's disease, biology.organism_classification, biology, Virus, Agriculture, business.industry, business, Statistics, Model selection, Viral evolution, Flock, Virus transmission, lcsh:Infectious and parasitic diseases, lcsh:RC109-216
Agricultural and Food Sciences
Rural Digital Europe
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Europe PubMed Central
Other literature type . 2018
Article . 2018
Provider: Crossref
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