The effects of Bee Venom and Sweet Bee Venom to the preadipocyte proliferation and lipolysis of adipocyte, localized fat accumulation

Article English OPEN
Min-Ki Kim ; Si Hyeong, Lee ; Jo Young Shin ; Kang San Kim ; Nam Guen Cho ; Ki Rok Kwon ; Tae Jin Rhim (2007)
  • Publisher: Korean Pharmacopuncture Institute
  • Journal: Journal of Pharmacopuncture (issn: 2093-6966, eissn: 2234-6856)
  • Related identifiers: doi: 10.3831/KPI.2007.10.3.005
  • Subject: Sweet Bee Venom | Medicine | preadipocyte | R | Venom | RM1-950 | Therapeutics. Pharmacology | Miscellaneous systems and treatments | lipolysis | adipocytes | RZ409.7-999
    mesheuropmc: behavior and behavior mechanisms | complex mixtures | fungi

Objectives : The purpose of this study was to investigate the effects of Bee Venom and Sweet Bee Venom to the primary cultured preadipocyte, adipocytes, and localized fat tissue. Methods : Decreased preadipocyte proliferation and decreased lipogenesis are mechanisms to reduce obesity. So, preadipocytes and adipocytes were performed on cell cultures using Sprague-Dawley Rats and treated with 0.01-1mg/㎖ Bee Venom and Sweet Bee Venom. And porcine skin including fat tissue after treated Bee Venom and Sweet Bee Venom according to the dosage dependent variation are investigated the histologic changes after injection of these Pharmacopuncture. Result : Following results were obtained from the preadipocyte proliferation and lipolysis of adipocyte and histologic investigation of fat tissue. 1. Bee Venom and Sweet Bee Venom showed the effect of decreased preadipocyte proliferation depend on concentration. 2. Bee Venom and Sweet Bee Venom showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) significantly. 3. Bee Venom was not showed the effect of lipolysis, but Sweet Bee Venom was increased in low dosage and decreased in high dosage. 4. Investigated the histologic changes in porcine fat tissue after treated Bee Venom and Sweet Bee Venom, we knew that these Pharmacopuncture was activated nonspecific lysis of cell membranes depend on concentration. Conclusion : These results suggest that Bee Venom and Sweet Bee Venom efficiently induces decreased proliferation of preadipocyte and lipolysis in adipose tissue
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