Insulin resistance in drug naive patients with multiple sclerosis

Article OPEN
Kostić Smiljana; Kolić Ivana; Raičević Ranko; Stojanović Zvezdana; Kostić Dejan; Dinčić Evica;
  • Publisher: Military Health Department, Ministry of Defance, Serbia
  • Journal: issn: 0042-8450, eissn: 2406-0720
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.2298/VSP160218082K
  • Subject: questionnaires | glucose tolerance test | test | R5-920 | multiple sclerosis | Medicine (General) | glucose tolerance | surveys and questionnaires | insulin resistance

Background/Aim. Due to the fact that there is a relatively small number of data related to systemic insulin abnormalities in the multiple sclerosis (MS), the main objective of our study was to determine whether a dysbalance of glucose and insulin metab... View more
  • References (43)
    43 references, page 1 of 5

    1. Compston A, Coles A, Bujko K, Bujko M. Multiple sclerosis. Lancet 2008; 372(9648): 1502−17.

    2. Hill JM, Lesniak MA, Pert CB, Roth J. Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas. Neuroscience 1986; 17(4): 1127−38.

    3. Woods SC, Seeley RJ, Baskin DG, Schwartz MW. Insulin and the blood-brain barrier. Curr Pharm Des 2003; 9(10): 795−800.

    4. Heni M, Kullmann S, Preissl H, Fritsche A, Häring HU. Impaired insulin action in the human brain: Causes and metabolic consequences. Nat Rev Endocrinol 2015; 11(12): 701−11.

    5. Banks WA, Illes P, Alexandre RJ. The source of cerebral insulin. Eur J Pharmacol 2004; 490(1−3): 5−12.

    6. Seaquist ER, Damberg GS, Tkac I, Gruetter R. The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans. Diabetes 2001; 50(10): 2203−9.

    7. Watson GS, Craft S. Insulin resistance, inflammation, and cognition in Alzheimer's Disease: Lessons for multiplesclerosis. J Neurol Sci 2006; 245(1−2): 21−33.

    8. Yanagita T, Nemoto T, Satoh S, Yoshikawa N, Maruta T, Shiraishi S, et al. Neuronal Insulin Receptor Signaling: A Potential Target for the Treatment of Cognitive and Mood Disorders.In: Kocabasoglu N, editor. Mood disorders. Rijeka: InTech; 2013. p. 263−87.

    9. Heni M, Schöpfer P, Peter A, Sartorius T, Fritsche A, Synofzik M, et al. Evidence for altered transport of insulin across the bloodbrain barrier in insulin-resistant humans. Acta Diabetol 2014; 51(4): 679−81.

    10. Russo CV, Salvatore E, Saccà F, Tucci T, Rinaldi C, Sorrentino P, et al. Insulin sensitivity and early-phase insulin secretion in normoglycemic Huntington's disease patients. J Huntingtons Dis 2013; 2(4): 501−7.

  • Related Organizations (5)
  • Metrics
Share - Bookmark