publication . Article . 2009

Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: Implications for cancer therapy

Vijay K Kalia; Prabhakara S; Vidya Narayanan;
Open Access English
  • Published: 01 Sep 2009 Journal: Journal of Cancer Research and Therapeutics, volume 5, issue 9, pages 57-60 (issn: 0973-1482, eissn: 1998-4138, Copyright policy)
  • Publisher: Wolters Kluwer Medknow Publications
Abstract
<b>Background:</b> 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, was observed earlier to increase DNA, chromosomal, and cellular damage in tumor cells, by inhibiting energy-dependent repair processes. Lonidamine (LND) selectively inhibits glycolysis in cancer cells. It damages the condensed mitochondria in these cells, impairing thereby the activity of hexokinase (predominantly attached to the outer mitochondrial membranes). It inhibits repair of radiation-induced potentially lethal cellular damage in HeLa and Chinese hamster (HA-1) cells. However, other than a preliminary study on human glioma (BMG-1) cells in this laboratory, the effects of LND on radiatio...
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free text keywords: Cytotoxicity, glioma cells, lonidamine, radiation damage, 2-deoxy-D-glucose, Oncology, Radiology Nuclear Medicine and imaging, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Cell growth, chemistry.chemical_compound, chemistry, Trypan blue, HeLa, biology.organism_classification, biology, Glioma, medicine.disease, medicine, Biochemistry, Cancer cell, Cancer research, Cell culture
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