publication . Article . 2013

Comparative analysis of the influence of Corvitin and Lipoflavon on parameters of energy metabolism in the brain of rats with experimental severe craniocerebral trauma

S. A. Zhilyaev; S. Yu. Shtrigol;
Open Access English
  • Published: 01 Apr 2013 Journal: Zaporožskij Medicinskij Žurnal (issn: 2306-4145, eissn: 2310-1210, Copyright policy)
  • Publisher: Zaporozhye State Medical University
Abstract
Hyperglycemia in rats develops in acute period of severe craniocerebral trauma: glucose consumption in rats’ brain increases, lactic acidosis develops, and the content of ATP decreases. Piracetam (200 mg/kg) does not eliminate hyperglycaemia but normalizes the level of intermediates of energy metabolism. Corvitin (100–150 mg/kg) eliminates hyperglycemia, normalizes the pyruvic and lactic acids, significantly increases the level of ATP. Lipoflavon (370 mg/kg) normalizes the blood level of glucose, increases the concentration of pyruvic and lactic acids, but it is worse than corvitin in its influence on ATP. Antihyperglycemic effect of lipoflavon is weaker at a do...
Subjects
free text keywords: craniocerebral trauma, corvitin, lipoflavon, energy metabolism, Medicine, R
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