Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner

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Gupta, Ram Prakash; Bajpai, Anjali; Sinha, Pradip;

(2017)

Publisher: The Company of Biologists

Journal: Biology Open, volume 6, issue 11, pages 1,581-1,591 (issn: 2046-6390, eissn: 2046-6390)

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Identifiers: doi: 10.1242/bio.027821, pmc: PMC5703612
Subject: Cooperative tumorigenesis | Q | Research Article | Drosophila | Cell fate | Science | Selector genes | Biology (General) | QH301-705.5
mesheuropmc: genetic structures | animal structures

ABSTRACT During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of ... View more

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Related Research Results (4)

Inferred by OpenAIRE

dataset Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment (2016)	73%
dataset Genome-Wide Tissue-Specific Occupancy of the Hox Protein Ultrabithorax and Hox Cofactor Homothorax in <em>Drosophila</em> (2016)	73%
dataset The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in <i>Drosophila melanogaster</i> through Maintaining a Progenitor-like Cell State (2016)	73%
dataset Genome-Wide Analysis of the Binding of the Hox Protein Ultrabithorax and the Hox Cofactor Homothorax in <em>Drosophila</em> (2016)	73%

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