Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner

Article English OPEN

Ram Prakash Gupta; Anjali Bajpai; Pradip Sinha;

(2017)

Publisher: The Company of Biologists

Journal: Biology Open,volume 6,issue 11,pages1,581-1,591 (issn: 2046-6390, eissn: 2046-6390)

Related identifiers: doi: 10.1242/bio.027821, pmc: PMC5703612
Subject: Cooperative tumorigenesis | Q | Research Article | Drosophila | Cell fate | Science | Selector genes | Biology (General) | QH301-705.5
mesheuropmc: genetic structures | animal structures

ABSTRACT During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of ... View more

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Related Research Results (4)

Inferred

Genome-Wide Analysis of the Binding of the Hox Protein Ultrabithorax and the Hox Cofactor Homothorax in <em>Drosophila</em> (2011)	73%
Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment (2016)	73%
The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in <i>Drosophila melanogaster</i> through Maintaining a Progenitor-like Cell State (2013)	73%
Genome-Wide Tissue-Specific Occupancy of the Hox Protein Ultrabithorax and Hox Cofactor Homothorax in <em>Drosophila</em> (2011)	73%

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