Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner

Article English OPEN

Gupta, Ram Prakash; Bajpai, Anjali; Sinha, Pradip;

(2017)

Publisher: The Company of Biologists Ltd

Journal: Biology Open,volume 6,issue 11,pages1,581-1,591 (issn: 2046-6390, eissn: 2046-6390)

Publisher copyright policies & self-archiving

Related identifiers: doi: 10.1242/bio.027821, pmc: PMC5703612
Subject: Cooperative tumorigenesis | Q | Research Article | Drosophila | Cell fate | Science | Selector genes | Biology (General) | QH301-705.5
mesheuropmc: genetic structures | animal structures

ABSTRACT During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of ... View more

References (72)
72 references, page 1 of 8
1
2
3
4
5
Abate-Shen C. (2002). Deregulated homeobox gene expression in cancer: cause or consequence? Nat. Rev. Cancer 2, 777-785. 10.1038/nrc907 12360280
Adachi-Yamada T. and O'Connor M. B. (2002). Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients. Dev Biol 251, 74-90. 10.1006/dbio.2002.0821 12413899
Agrawal N., Kango M., Mishra A. and Sinha P. (1995). Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila. Dev. Biol. 172, 218-229. 10.1006/dbio.1995.0017 7589802
Akam M. (1998). Hox genes: from master genes to micromanagers. Curr. Biol. 8, R676-R678. 10.1016/S0960-9822(98)70433-6 9768351
Ayala-Camargo A., Anderson A. M., Amoyel M., Rodrigues A. B., Flaherty M. S. and Bach E. A. (2013). JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc. Dev. Biol. 382, 413-426. 10.1016/j.ydbio.2013.08.016 23978534
Azpiazu N. and Morata G. (2000). Function and regulation of homothorax in the wing imaginal disc of Drosophila. Development 127, 2685-2693.10821766
Bessa J. and Casares F. (2005). Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila. Development 132, 5011-5020. 10.1242/dev.02082 16221726
Bessa J., Gebelein B., Pichaud F., Casares F. and Mann R. S. (2002). Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. Genes Dev. 16, 2415-2427. 10.1101/gad.1009002 12231630
Beuchle D., Struhl G. and Müller J. (2001). Polycomb group proteins and heritable silencing of Drosophila Hox genes. Development 128, 993-1004.11222153
Bhagwat A. S. and Vakoc C. R. (2015). Targeting transcription factors in cancer. Trends Cancer 1, 53-65. 10.1016/j.trecan.2015.07.001 26645049

Related Research Results (4)

Inferred by OpenAIRE

other Genome-Wide Tissue-Specific Occupancy of the Hox Protein Ultrabithorax and Hox Cofactor Homothorax in <em>Drosophila</em> (2011)	73%
other Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment (2016)	73%
other Genome-Wide Analysis of the Binding of the Hox Protein Ultrabithorax and the Hox Cofactor Homothorax in <em>Drosophila</em> (2011)	73%
other The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in <i>Drosophila melanogaster</i> through Maintaining a Progenitor-like Cell State (2013)	73%

Metrics

Share - Bookmark

Download from
Europe PubMed Central via PubMed Central (Article, 2017)
Biology Open via DOAJ-Articles (Article, 2017)
The Company of Biologists Ltd/ Biology Open
Funded by
WT
Cite this publication