publication . Article . 2015

Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

N.V. Zaitseva; O.V. Dolgilh; A.V. Krivtsov; K.G. Starkova; V.A. Luchnikova; O.A. Bubnov; E.A. Otavina; N.V. Bezruchenko; N.A. Vdovina;
Open Access English
  • Published: 01 Dec 2015 Journal: Analiz Riska Zdorovʹû (issn: 2308-1155, eissn: 2308-1163, Copyright policy)
  • Publisher: FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1) and methylenetetrahydrofolate. It was shown that the structure of the mutations in conditions of the strontium exposure was characterized by the formation of defects in the gene mapping detox...
Medical Subject Headings: inorganic chemicalsmusculoskeletal diseases
free text keywords: sequencing, strontium, candidate genes, gene polymorphism, Medicine, R
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