Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells

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Mologni, L; Costanza, M; Sharma, G; Viltadi, M; Massimino, L; Citterio, S; Purgante, S; Raman, H; Pirola, A; Zucchetti, M; Piazza, R; Gambacorti-Passerini, C;
(2018)

BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival co... View more
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