Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors

Article English OPEN
Boris Pinchuk ; Rebecca Horbert ; Alexander Döbber ; Lydia Kuhl ; Christian Peifer (2016)
  • Publisher: MDPI AG
  • Journal: Molecules (issn: 1420-3049)
  • Related identifiers: doi: 10.3390/molecules21050570
  • Subject: photoactivatable prodrugs | caging | receptor tyrosine kinase | kinase inhibitors | VEGFR-2 | 3,4-diarylmaleimides | photoremovable protecting group (PPG) | Organic chemistry | QD241-441

In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protec... View more
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