publication . Article . 2017

Activation of Transient Receptor Potential Vanilloid 4 Impairs the Dendritic Arborization of Newborn Neurons in the Hippocampal Dentate Gyrus through the AMPK and Akt Signaling Pathways.

Yujing Tian; Mengwen Qi; Zhouqing Wang; Chunfeng Wu; Zhen Sun; Yingchun Li; Sha Sha; Yimei Du; Lei Chen; Lei Chen; ...
Open Access English
  • Published: 15 Jun 2017 Journal: Frontiers in Molecular Neuroscience (issn: 1662-5099, Copyright policy)
  • Publisher: Frontiers Media S.A.
Neurite growth is an important process for the adult hippocampal neurogenesis which is regulated by a specific range of the intracellular free Ca2+ concentration ([Ca2+]i). Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable channel and activation of it causes an increase in [Ca2+]i. We recently reported that TRPV4 activation promotes the proliferation of stem cells in the adult hippocampal dentate gyrus (DG). The present study aimed to examine the effect of TRPV4 activation on the dendrite morphology of newborn neurons in the adult hippocampal DG. Here, we report that intracerebroventricular injection of the TRPV4 agonist GSK1016790A for 5 d...
free text keywords: TRPV4, dendritic arborization, calcium, AMPK, Akt, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neuroscience, Original Research, Molecular Biology, Cellular and Molecular Neuroscience, Endocrinology, medicine.medical_specialty, medicine, Dentate gyrus, Hippocampal formation, Protein kinase A, P70-S6 Kinase 1, Doublecortin, biology.protein, biology, Protein kinase B, Internal medicine, Neurogenesis
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55 references, page 1 of 4

Alvarez-Buylla A. Garcia-Verdugo J. M. (2002). Neurogenesis in adult subventricular zone. J. Neurosci. 22 629–634. [OpenAIRE]

Amato S. Liu X. Zheng B. Cantley L. Rakic P. Man H. Y. (2011). AMP-activated protein kinase regulates neuronal polarization by interfering with PI3-kinase localization. Science 332 247–251. 10.1126/science.1201678 [OpenAIRE] [DOI]

Amato S. Man H. Y. (2012). AMPK signaling in neuronal polarization: putting the brakes on axonal traffic of PI3-kinase. Commun. Integr. Biol. 5 152–155. 10.4161/cib.18968 [OpenAIRE] [DOI]

Balu D. T. Lucki I. (2009). Adult hippocampal neurogenesis: regulation, function implications and contribution to disease pathology. Neurosci. Biobehav. Rev. 33 232–252. 10.1016/j.neubiorev.2008.08.007 [OpenAIRE] [DOI]

Benemei S. Patacchini R. Trevisani M. Geppetti P. (2015). TRP channels. Curr. Opin. Pharmacol. 22 18–23. 10.1016/j.coph.2015.02.006 [OpenAIRE] [DOI]

Bhat R. V. Shanley J. Correll M. P. Fieles W. E. Keith R. A. Scott C. W. (2000). Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. Proc. Natl. Acad. Sci. U.S.A. 97 11074–11079. 10.1073/pnas.190297597 [OpenAIRE] [DOI]

Cohen M. R. Johnson W. M. Pilat J. M. Kiselar J. DeFrancesco-Lisowitz A. Zigmond R. E. (2015). Nerve growth factor regulates transient receptor potential vanilloid 2 via extracellular signal-regulated kinase signaling to enhance neurite outgrowth in developing neurons. Mol. Cell. Biol. 35 k4238–4252. 10.1128/MCB.00549-15 [DOI]

Cross D. A. Alessi D. R. Cohen P. Andjelkovich M. Hemmings B. A. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 785–789. 10.1038/378785a0 [OpenAIRE] [DOI]

Damm E. Buech T. R. Gudermann T. (2012). Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells. Mol. Endocrinol. 26 643–654. 10.1210/me.2011-1218 [OpenAIRE] [DOI]

Derossi D. Williams E. J. Green P. J. Dunican D. J. Doherty P. (1998). Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem. Biophys. Res. Commun. 251 148–152. 10.1006/bbrc.1998.9444 [OpenAIRE] [DOI]

Duan X. Kang E. Liu C. Y. Ming G. L. Song H. (2008). Development of neural stem cell in the adult brain. Curr. Opin. Neurobiol. 18 108–115. 10.1016/j.conb.2008.04.001 [OpenAIRE] [DOI]

Fecto F. Shi Y. Huda R. Martina M. Siddique T. Deng H. X. (2011). Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies. J. Biol. Chem. 286 17281–17291. 10.1074/jbc.M111.237685 [DOI]

Ge S. Sailor K. A. Ming G. L. (2008). Synaptic integration and plasticity of new neurons in the adult hippocampus. J. Physiol. 586 3759–3765. 10.1113/jphysiol.2008.155655 [OpenAIRE] [DOI]

Greka A. Navarro B. Oancea E. Duggan A. Clapham D. E. (2003). TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. 6 837–845. 10.1038/nn1092 [OpenAIRE] [DOI]

Han S. M. Namkoong C. Jang P. G. Park I. S. Hong S. W. Katakami H. (2005). Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats. Diabetologia 48 2170–2178. 10.1007/s00125-005-1913-1 [OpenAIRE] [DOI]

55 references, page 1 of 4
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