publication . Article . 2013

Protective effect of hydrogen on diabetic peripheral neuropathy by suppressing nulcear factor-kappaB pathway

Yang JIAO; Yang YU; Bo LI; Yong-hao YU;
Open Access English
  • Published: 01 Sep 2013 Journal: Chinese Journal of Contemporary Neurology and Neurosurgery (issn: 1672-6731, Copyright policy)
  • Publisher: Tianjin Huanhu Hospital
Abstract
<strong>Objective</strong> To investigate the effect of hydrogen on streptozotocin (STZ)-induced diabetic rat models with peripheral neuropathy and explore the possible mechanism. <strong>Methods</strong> Eighteen male Sprague⁃Dawley (SD) rats were randomly divided into model group (N = 6), hydrogen-treated group (N = 6) and normal control group (N = 6). After fasting for 12 h, experimental diabetic rat models were established by intraperitoneal injection of STZ (65 mg/kg of single dose), while normal control group only received a same dose of citrate buffer. Diabetes was confirmed with a fasting plasma glucose more than 16.67 mmol/L 48 h after STZ injection. Af...
Subjects
free text keywords: Neuralgia, Diabetic neuropathies, Hydrogen, NF-kappa B, Tumor necrosis factor-alpha, Interleukin-6, Disease models, animal, Neurology. Diseases of the nervous system, RC346-429
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