publication . Article . 2014

In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer

Resmi Mustarichiei; Jutti Levitas; Jopi Arpina;
Open Access English
  • Published: 01 Mar 2014 Journal: Medical Journal of Indonesia, volume 23, issue 1, pages 15-24 (issn: 0853-1773, eissn: 2252-8083, Copyright policy)
  • Publisher: Faculty of Medicine Universitas Indonesia
Abstract
<p><strong>Background:</strong> Based on data from the Hospital Information System (HIS) in 2007, breast cancer is the top ranked diagnosed cancer in Indonesia. Estrogen receptor alpha (ERα) is associated with breast cancer because it is found in high levels in cancer tissues. Curcumol, curcumenol, isocurcumenol of white tumeric rhizomes (<em>Curcuma zedoaria</em> (<em>Christm</em>.) <em>Roscoe</em>), and β-sitosterol from seeds of pumpkin (<em>Cucurbita pepo L.</em>) have been reported to have inhibitory activity against cancer cells. This study presents the in silico study of these compounds as inhibitors of ERα.<br /><br /><strong>Methods:</strong> Docking si...
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Subjects
free text keywords: General Medicine, lcsh:Medicine (General), lcsh:R5-920, Estrogen receptor alpha, Pharmacology, Tamoxifen, medicine.drug, medicine, Curcuma zedoaria, food.food, food, Biology, Breast cancer, medicine.disease, Cancer, Docking (dog), Cancer cell, Cytotoxicity
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